Playing with the molecules of life #MMPMID29345901
Young DD; Schultz PG
ACS Chem Biol 2018[Apr]; 13 (4): 854-70 PMID29345901show ga
Our understanding of the complex processes of living organisms at the molecular level is growing exponentially. This knowledge, together with a powerful arsenal of tools for manipulating the structures of macromolecules, is allowing chemists to harness and reprogram the cellular machinery. Here we review one example in which the genetic code itself has been expanded with new building blocks that allow us to probe and manipulate the structures and functions of proteins in ways previously unimaginable