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Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial
Tissue Correlates in Acute Myocardial Infarction
#MMPMID30062203
de Carvalho LP
; Tan SH
; Ow GS
; Tang Z
; Ching J
; Kovalik JP
; Poh SC
; Chin CT
; Richards AM
; Martinez EC
; Troughton RW
; Fong AY
; Yan BP
; Seneviratna A
; Sorokin V
; Summers SA
; Kuznetsov VA
; Chan MY
JACC Basic Transl Sci
2018[Apr]; 3
(2
): 163-175
PMID30062203
show ga
We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16
dihydroceramide predictive of major adverse cardiovascular events in patients
with acute myocardial infarction (AMI). Among patients undergoing coronary artery
bypass surgery, those with recent AMI, compared with those without recent AMI,
showed a significant increase in 5 of the signature's 12 ceramides in plasma but
not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared
with sham control, showed a significant increase in myocardial concentrations of
all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting
ischemic myocardium as a possible source of this ceramide signature.