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10.1016/j.jacbts.2017.12.005

http://scihub22266oqcxt.onion/10.1016/j.jacbts.2017.12.005
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suck abstract from ncbi

pmid30062203
      JACC+Basic+Transl+Sci 2018 ; 3 (2 ): 163-175
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  • Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction #MMPMID30062203
  • de Carvalho LP ; Tan SH ; Ow GS ; Tang Z ; Ching J ; Kovalik JP ; Poh SC ; Chin CT ; Richards AM ; Martinez EC ; Troughton RW ; Fong AY ; Yan BP ; Seneviratna A ; Sorokin V ; Summers SA ; Kuznetsov VA ; Chan MY
  • JACC Basic Transl Sci 2018[Apr]; 3 (2 ): 163-175 PMID30062203 show ga
  • We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature's 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature.
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