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10.4172/2161-1149.1000235 http://scihub22266oqcxt.onion/10.4172/2161-1149.1000235 C6059963!6059963!30057856     free     free     free       Rheumatology+(Sunnyvale) 2018 ; 8 (1): ä Nephropedia Template TP {{tp|p=30057856|t=2018. Gastrointestinal Manifestations of Systemic Sclerosis |pdf=|usr=}}{{30057856}} gab.com Text Gastrointestinal Manifestations of Systemic Sclerosis JO: Rheumatology (Sunnyvale) http://www.kidney.de/pget.php?&tw=1&pmid=30057856 #FOAvip Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibroproliferative alterations of the microvasculature leading to fibrosis and loss of function of the skin and internal organs. Gastrointestinal manifestations of SSc are the most commonly encountered complications of the disease affecting nearly 90% of the SSc population. Among these complications, the esophagus and the anorectum are the most commonly affected. However, this devastating disorder does not spare any part of the gastrointestinal tract (GIT), and includes the oral cavity, esophagus, stomach, small and large bowels as well as the liver and pancreas. In this review, we present the current understanding of the pathophysiologic mechanisms of SSc including vasculopathy, endothelial to mesenchymal transformation as well as the autoimmune pathogenetic pathways. We also discuss the clinical presentation and diagnosis of each part of the GIT affected by SSc. Finally, we highlight the latest developments in the management of this disease, addressing the severe malnutrition that affects this vulnerable patient population and ways to assess and improve the nutritional status of the patients. Twit Text FOAVip Gastrointestinal Manifestations of Systemic Sclerosis ????Rheumatology (Sunnyvale) http://www.kidney.de/pget.php?&tw=1&pmid=30057856 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30057856 #FOAvip English Wikipedia <ref>{{Cite pmid|30057856}}</ref> Gastrointestinal Manifestations of Systemic Sclerosis #MMPMID30057856 McFarlane IM; Bhamra MS; Kreps A; Iqbal S; Al-Ani F; Saladini-Aponte C; Grant C; Singh S; Awwal K; Koci K; Saperstein Y; Arroyo-Mercado FM; Laskar DB; Atluri P Rheumatology (Sunnyvale) 2018[]; 8 (1): ä PMID30057856show ga Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibroproliferative alterations of the microvasculature leading to fibrosis and loss of function of the skin and internal organs. Gastrointestinal manifestations of SSc are the most commonly encountered complications of the disease affecting nearly 90% of the SSc population. Among these complications, the esophagus and the anorectum are the most commonly affected. However, this devastating disorder does not spare any part of the gastrointestinal tract (GIT), and includes the oral cavity, esophagus, stomach, small and large bowels as well as the liver and pancreas. In this review, we present the current understanding of the pathophysiologic mechanisms of SSc including vasculopathy, endothelial to mesenchymal transformation as well as the autoimmune pathogenetic pathways. We also discuss the clinical presentation and diagnosis of each part of the GIT affected by SSc. Finally, we highlight the latest developments in the management of this disease, addressing the severe malnutrition that affects this vulnerable patient population and ways to assess and improve the nutritional status of the patients. äGastrointestinal Manifestations of Systemic Sclerosis (epmc).pdf DeepDyve Pubget Overpricing