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10.3892/or.2018.6399 http://scihub22266oqcxt.onion/10.3892/or.2018.6399 C6059743!6059743 !29749458     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29749458 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncol+Rep 2018 ; 40 (1 ): 217-225 Nephropedia Template TP {{tp|p=29749458 |t=2018. ?Klotho inhibits androgen/androgen receptor?associated epithelial?mesenchymal transition in prostate cancer through inactivation of ERK1/2 signaling |pdf=|usr=}}{{29749458 }} gab.com Text Klotho inhibits androgen/androgen receptor associated epithelial mesenchymal transition in prostate cancer through inactivation of ERK1/2 signaling JO: Oncol Rep http://www.kidney.de/pget.php?&tw=1&pmid=29749458 #FOAvip The epithelial?mesenchymal transition (EMT) is reported to have intimate crosstalk with androgen receptor (AR) signaling in prostate cancer (PCa) and is known to be responsible for castration resistance. Fibroblast growth factor/receptor (FGF/FGFR) signaling is also involved in tumor progression and EMT in multiple tissues. Several studies have investigated the role of ?Klotho, an FGF/FGFR signaling co?receptor in tumorigenesis. However, its role in PCa remains unknown. In the present study, the role of androgen in the EMT of PCa cells was examined by western blotting. The expression of ?Klotho was examined in prostate cells and PCa tissues by western blotting and immunohistochemistry, respectively. The biological role of ?Klotho was revealed by a series of functional in vitro and in vivo studies. We determined that ?Klotho expression was significantly decreased in PCa tissues compared with benign prostatic hyperplasia (BPH) tissues, and low ?Klotho expression was associated with a high Gleason score of PCa. ?Klotho overexpression inhibited the viability, migration, and androgen/AR?associated EMT of PCa cells through the inactivation of ERK1/2 signaling. Notably, ?Klotho overexpression inhibited prostate tumor growth and EMT in vivo. Knockdown of ?Klotho produced the opposite effects. In conclusion, ?Klotho inhibits EMT and plays a tumor?suppressive role in PCa, linking FGF/FGFR/?Klotho signaling to the regulation of PCa progression. Twit Text FOAVip Klotho inhibits androgen/androgen receptor associated epithelial mesenchymal transition in prostate cancer through inactivation of ERK1/2 signaling ????Oncol Rep http://www.kidney.de/pget.php?&tw=1&pmid=29749458 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29749458 #FOAvip English Wikipedia <ref>{{Cite pmid|29749458 }}</ref> ?Klotho inhibits androgen/androgen receptor?associated epithelial?mesenchymal transition in prostate cancer through inactivation of ERK1/2 signaling #MMPMID29749458 Liu Z ; Zhang H ; Ding S ; Qi S ; Liu S ; Sun D ; Dong W ; Yin L ; Li M ; Zhao X ; Lu J Oncol Rep 2018[Jul]; 40 (1 ): 217-225 PMID29749458 show ga The epithelial?mesenchymal transition (EMT) is reported to have intimate crosstalk with androgen receptor (AR) signaling in prostate cancer (PCa) and is known to be responsible for castration resistance. Fibroblast growth factor/receptor (FGF/FGFR) signaling is also involved in tumor progression and EMT in multiple tissues. Several studies have investigated the role of ?Klotho, an FGF/FGFR signaling co?receptor in tumorigenesis. However, its role in PCa remains unknown. In the present study, the role of androgen in the EMT of PCa cells was examined by western blotting. The expression of ?Klotho was examined in prostate cells and PCa tissues by western blotting and immunohistochemistry, respectively. The biological role of ?Klotho was revealed by a series of functional in vitro and in vivo studies. We determined that ?Klotho expression was significantly decreased in PCa tissues compared with benign prostatic hyperplasia (BPH) tissues, and low ?Klotho expression was associated with a high Gleason score of PCa. ?Klotho overexpression inhibited the viability, migration, and androgen/AR?associated EMT of PCa cells through the inactivation of ERK1/2 signaling. Notably, ?Klotho overexpression inhibited prostate tumor growth and EMT in vivo. Knockdown of ?Klotho produced the opposite effects. In conclusion, ?Klotho inhibits EMT and plays a tumor?suppressive role in PCa, linking FGF/FGFR/?Klotho signaling to the regulation of PCa progression. |Androgens/genetics/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Movement/genetics [MESH] |Cell Proliferation/genetics [MESH] |Epithelial-Mesenchymal Transition/genetics [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Klotho Proteins [MESH] |MAP Kinase Signaling System/genetics [MESH] |Male [MESH] |Membrane Proteins/*genetics [MESH] |Neoplasm Grading [MESH] |Prostate/metabolism/pathology [MESH] |Prostatic Hyperplasia/*genetics/pathology [MESH] |Prostatic Neoplasms/*genetics/pathology [MESH]?Klotho inhibits androgen/androgen receptor?associated epithelial?mese(epmc).pdf DeepDyve Pubget Overpricing