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10.1126/sciadv.aat0979 http://scihub22266oqcxt.onion/10.1126/sciadv.aat0979 C6059731!6059731 !30050988     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30050988 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Adv 2018 ; 4 (7 ): eaat0979 Nephropedia Template TP {{tp|p=30050988 |t=2018. Human ?-defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization |pdf=|usr=}}{{30050988 }} gab.com Text Human -defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=30050988 #FOAvip Human defensins belong to a subfamily of the cationic antimicrobial peptides and act as a first line of defense against invading microbes. Their often broad-spectrum antimicrobial and antitumor activities make them attractive for therapeutic development; however, their precise molecular mechanism(s) of action remains to be defined. We show that human ?-defensin 2 (HBD-2) permeabilizes Candida albicans cell membranes via a mechanism targeting the plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)). We determined the structure of HBD-2 bound to PIP(2), which revealed two distinct PIP(2)-binding sites, and showed, using functional assays, that mutations in these sites ablate PIP(2)-mediated fungal growth inhibition by HBD-2. Our study provides the first insight into lipid-mediated human defensin membrane permeabilization at an atomic level and reveals a unique mode of lipid engagement to permeabilize cell membranes. Twit Text FOAVip Human -defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=30050988 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30050988 #FOAvip English Wikipedia <ref>{{Cite pmid|30050988 }}</ref> Human ?-defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization #MMPMID30050988 Järvå M ; Phan TK ; Lay FT ; Caria S ; Kvansakul M ; Hulett MD Sci Adv 2018[Jul]; 4 (7 ): eaat0979 PMID30050988 show ga Human defensins belong to a subfamily of the cationic antimicrobial peptides and act as a first line of defense against invading microbes. Their often broad-spectrum antimicrobial and antitumor activities make them attractive for therapeutic development; however, their precise molecular mechanism(s) of action remains to be defined. We show that human ?-defensin 2 (HBD-2) permeabilizes Candida albicans cell membranes via a mechanism targeting the plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)). We determined the structure of HBD-2 bound to PIP(2), which revealed two distinct PIP(2)-binding sites, and showed, using functional assays, that mutations in these sites ablate PIP(2)-mediated fungal growth inhibition by HBD-2. Our study provides the first insight into lipid-mediated human defensin membrane permeabilization at an atomic level and reveals a unique mode of lipid engagement to permeabilize cell membranes. |Binding Sites [MESH] |Candida albicans/*drug effects [MESH] |Cell Wall/drug effects [MESH] |Crystallography, X-Ray [MESH] |Humans [MESH] |Molecular Dynamics Simulation [MESH] |Permeability/drug effects [MESH] |Phosphatidylinositol 4,5-Diphosphate/chemistry/*metabolism [MESH] |Protein Binding [MESH] |Protein Conformation [MESH] |Static Electricity [MESH]Human ?-defensin 2 kills Candida albicans through phosphatidylinositol(epmc).pdf DeepDyve Pubget Overpricing