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10.3892/mmr.2018.9061 http://scihub22266oqcxt.onion/10.3892/mmr.2018.9061 C6059727!6059727 !29845238     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29845238 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2018 ; 18 (1 ): 945-957 Nephropedia Template TP {{tp|p=29845238 |t=2018. Matrine inhibits prostate cancer via activation of the unfolded protein response/endoplasmic reticulum stress signaling and reversal of epithelial to mesenchymal transition |pdf=|usr=}}{{29845238 }} gab.com Text Matrine inhibits prostate cancer via activation of the unfolded protein response/endoplasmic reticulum stress signaling and reversal of epithelial to mesenchymal transition JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=29845238 #FOAvip Prostate cancer is the second most commonly diagnosed malignancy and the sixth global primary cause of malignancy?associated fatality. Increased invasiveness and motility in prostate cancer cells are associated with ubiquitin proteasome system?regulated epithelial to mesenchymal transition (EMT). Impairment of the endoplasmic reticulum (ER) causes ER stress due to the accumulation of unfolded proteins and altered cell survival. In the current study, the effect and mechanism of matrine on cell apoptosis, viability, migration and invasion of human prostate cancer cells in vivo and in vitro through the unfolded protein response (UPR)/ER stress pathway were investigated. Matrine inhibited proteasomal chymotrypsin?like (CT?like) activity in the prostate carcinoma cellular proteasome. Upregulated vimentin and N?cadherin and downregulated E?cadherin were also observed in vitro and in vivo. In vitro analyses showed that matrine repressed cell motility, viability and invasion, arrested the cell cycle at the G0/G1 phase and induced prostate cancer cell apoptosis. Furthermore, matrine activated the UPR/ER stress signaling cascade in prostate cancer cells and tumor tissues of xenograft?bearing nude mice. Results also demonstrated that the anti?apoptotic protein Bcl?2 was downregulated, the pro?apoptotic protein Bak was upregulated and the cell growth and cell cycle?related proteins c?Myc, Cyclin B1, Cyclin D1 and CDK1 were downregulated. Moreover, matrine inhibited tumor growth and Ki?67 expression in xenograft?bearing nude mice. To the best of our knowledge, the present study indicated for the first time that matrine exerted marked anticancer functions in human prostate carcinoma in vivo and in vitro through activation of the proteasomal CT?like activity inhibition mediated by the UPR/ER stress signaling pathway. Twit Text FOAVip Matrine inhibits prostate cancer via activation of the unfolded protein response/endoplasmic reticulum stress signaling and reversal of epithelial to mesenchymal transition ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=29845238 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29845238 #FOAvip English Wikipedia <ref>{{Cite pmid|29845238 }}</ref> Matrine inhibits prostate cancer via activation of the unfolded protein response/endoplasmic reticulum stress signaling and reversal of epithelial to mesenchymal transition #MMPMID29845238 Chang J ; Hu S ; Wang W ; Li Y ; Zhi W ; Lu S ; Shi Q ; Wang Y ; Yang Y Mol Med Rep 2018[Jul]; 18 (1 ): 945-957 PMID29845238 show ga Prostate cancer is the second most commonly diagnosed malignancy and the sixth global primary cause of malignancy?associated fatality. Increased invasiveness and motility in prostate cancer cells are associated with ubiquitin proteasome system?regulated epithelial to mesenchymal transition (EMT). Impairment of the endoplasmic reticulum (ER) causes ER stress due to the accumulation of unfolded proteins and altered cell survival. In the current study, the effect and mechanism of matrine on cell apoptosis, viability, migration and invasion of human prostate cancer cells in vivo and in vitro through the unfolded protein response (UPR)/ER stress pathway were investigated. Matrine inhibited proteasomal chymotrypsin?like (CT?like) activity in the prostate carcinoma cellular proteasome. Upregulated vimentin and N?cadherin and downregulated E?cadherin were also observed in vitro and in vivo. In vitro analyses showed that matrine repressed cell motility, viability and invasion, arrested the cell cycle at the G0/G1 phase and induced prostate cancer cell apoptosis. Furthermore, matrine activated the UPR/ER stress signaling cascade in prostate cancer cells and tumor tissues of xenograft?bearing nude mice. Results also demonstrated that the anti?apoptotic protein Bcl?2 was downregulated, the pro?apoptotic protein Bak was upregulated and the cell growth and cell cycle?related proteins c?Myc, Cyclin B1, Cyclin D1 and CDK1 were downregulated. Moreover, matrine inhibited tumor growth and Ki?67 expression in xenograft?bearing nude mice. To the best of our knowledge, the present study indicated for the first time that matrine exerted marked anticancer functions in human prostate carcinoma in vivo and in vitro through activation of the proteasomal CT?like activity inhibition mediated by the UPR/ER stress signaling pathway. |Alkaloids/*pharmacology [MESH] |Cell Line, Tumor [MESH] |Endoplasmic Reticulum Stress/*drug effects [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Humans [MESH] |Male [MESH] |Matrines [MESH] |Prostatic Neoplasms/*drug therapy/metabolism [MESH] |Quinolizines/*pharmacology [MESH]Matrine inhibits prostate cancer via activation of the unfolded protei(epmc).pdf DeepDyve Pubget Overpricing