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10.3892/mmr.2018.9023 http://scihub22266oqcxt.onion/10.3892/mmr.2018.9023 C6059723!6059723 !29845189     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29845189 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2018 ; 18 (1 ): 911-919 Nephropedia Template TP {{tp|p=29845189 |t=2018. Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial?mesenchymal transition |pdf=|usr=}}{{29845189 }} gab.com Text Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial mesenchymal transition JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=29845189 #FOAvip Matrine has been reported to be an effective anti?tumor therapy; however, the anti-metastatic effects of matrine on hepatocellular carcinoma (HCC) and the molecular mechanism(s) involved remain unclear. Therefore, the aims of the present study were to evaluate the effects of matrine on hepatoma and to determine the associated mechanism(s) involved. In the present study, matrine was confirmed to prevent the proliferation of HCC cells and it was observed that matrine also inhibited the migratory, and invasive capabilities of HCC at non?toxic concentrations. Additionally, matrine increased epithelial?cadherin expression and decreased the expression levels of vimentin, matrix metalloproteinase (MMP)2, MMP9, zinc finger protein SNAI1 and zinc finger protein SNAI2. These results indicate that the anti?metastatic effect of matrine may be associated with epithelial?mesenchymal transition (EMT). Furthermore, matrine can increase phosphatidylinositol 3,4,5?trisphosphate 3?phosphatase and dual?specificity protein phosphatase PTEN (PTEN) expression and reduce phosphorylated?protein kinase B (Akt) levels. In conclusion, these results suggested that matrine is a potential therapeutic agent that can suppress cancer?associated invasion and migration via PTEN/Akt?dependent inhibition of EMT. Twit Text FOAVip Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial mesenchymal transition ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=29845189 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29845189 #FOAvip English Wikipedia <ref>{{Cite pmid|29845189 }}</ref> Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial?mesenchymal transition #MMPMID29845189 Wang Y ; Zhang S ; Liu J ; Fang B ; Yao J ; Cheng B Mol Med Rep 2018[Jul]; 18 (1 ): 911-919 PMID29845189 show ga Matrine has been reported to be an effective anti?tumor therapy; however, the anti-metastatic effects of matrine on hepatocellular carcinoma (HCC) and the molecular mechanism(s) involved remain unclear. Therefore, the aims of the present study were to evaluate the effects of matrine on hepatoma and to determine the associated mechanism(s) involved. In the present study, matrine was confirmed to prevent the proliferation of HCC cells and it was observed that matrine also inhibited the migratory, and invasive capabilities of HCC at non?toxic concentrations. Additionally, matrine increased epithelial?cadherin expression and decreased the expression levels of vimentin, matrix metalloproteinase (MMP)2, MMP9, zinc finger protein SNAI1 and zinc finger protein SNAI2. These results indicate that the anti?metastatic effect of matrine may be associated with epithelial?mesenchymal transition (EMT). Furthermore, matrine can increase phosphatidylinositol 3,4,5?trisphosphate 3?phosphatase and dual?specificity protein phosphatase PTEN (PTEN) expression and reduce phosphorylated?protein kinase B (Akt) levels. In conclusion, these results suggested that matrine is a potential therapeutic agent that can suppress cancer?associated invasion and migration via PTEN/Akt?dependent inhibition of EMT. |Alkaloids/*pharmacology [MESH] |Carcinoma, Hepatocellular/drug therapy/*metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/*drug effects [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Humans [MESH] |Liver Neoplasms/drug therapy/*metabolism/pathology [MESH] |Matrines [MESH] |Neoplasm Invasiveness [MESH]Matrine inhibits the invasive and migratory properties of human hepato(epmc).pdf DeepDyve Pubget Overpricing