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10.3892/mmr.2018.8987 http://scihub22266oqcxt.onion/10.3892/mmr.2018.8987 C6059665!6059665 !29749509     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29749509 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2018 ; 18 (1 ): 16-24 Nephropedia Template TP {{tp|p=29749509 |t=2018. Long noncoding RNA KCNQ1OT1 promotes proliferation and epithelial?mesenchymal transition by regulation of SMAD4 expression in lens epithelial cells |pdf=|usr=}}{{29749509 }} gab.com Text Long noncoding RNA KCNQ1OT1 promotes proliferation and epithelial mesenchymal transition by regulation of SMAD4 expression in lens epithelial cells JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=29749509 #FOAvip Long noncoding RNAs (lncRNAs) are associated with various diseases including cataracts. The role of lncRNA potassium voltage?gated channel subfamily Q member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) on lens epithelial cell (LEC) proliferation and epithelial?mesenchymal transition (EMT) in cataracts disease remains unclear. In the present study, KCNQ1OT1 and mothers against decapentaplegic homolog (SMAD)4 expression levels were upregulated in human cataract lens posterior capsular samples and in transforming growth factor (TGF)??2?treated SRA01/04 cells, as demonstrated by reverse transcription?quantitative polymerase chain reaction, immunohistochemical staining and western blot analyses. A further loss of function test revealed that suppression of KCNQ1OT1 inhibited the proliferation and EMT of TGF??2?treated SRA01/04 cells. Additionally, the present study reported that increase and decrease of KCNQ1OT1 regulated SMAD4 expression, which indicated that SMAD4 may be a downstream gene of KCNQ1OT1. Finally, a constructed SMAD4 RNA interference experiment confirmed that the function of KCNQ1OT1 was to act on LEC proliferation and EMT, and this was achieved via the SMAD4 signaling pathway. The findings of the present study may provide a novel target for molecular therapy of cataracts disease. Twit Text FOAVip Long noncoding RNA KCNQ1OT1 promotes proliferation and epithelial mesenchymal transition by regulation of SMAD4 expression in lens epithelial cells ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=29749509 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29749509 #FOAvip English Wikipedia <ref>{{Cite pmid|29749509 }}</ref> Long noncoding RNA KCNQ1OT1 promotes proliferation and epithelial?mesenchymal transition by regulation of SMAD4 expression in lens epithelial cells #MMPMID29749509 Chen B ; Ma J ; Li C ; Wang Y Mol Med Rep 2018[Jul]; 18 (1 ): 16-24 PMID29749509 show ga Long noncoding RNAs (lncRNAs) are associated with various diseases including cataracts. The role of lncRNA potassium voltage?gated channel subfamily Q member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) on lens epithelial cell (LEC) proliferation and epithelial?mesenchymal transition (EMT) in cataracts disease remains unclear. In the present study, KCNQ1OT1 and mothers against decapentaplegic homolog (SMAD)4 expression levels were upregulated in human cataract lens posterior capsular samples and in transforming growth factor (TGF)??2?treated SRA01/04 cells, as demonstrated by reverse transcription?quantitative polymerase chain reaction, immunohistochemical staining and western blot analyses. A further loss of function test revealed that suppression of KCNQ1OT1 inhibited the proliferation and EMT of TGF??2?treated SRA01/04 cells. Additionally, the present study reported that increase and decrease of KCNQ1OT1 regulated SMAD4 expression, which indicated that SMAD4 may be a downstream gene of KCNQ1OT1. Finally, a constructed SMAD4 RNA interference experiment confirmed that the function of KCNQ1OT1 was to act on LEC proliferation and EMT, and this was achieved via the SMAD4 signaling pathway. The findings of the present study may provide a novel target for molecular therapy of cataracts disease. |*Cell Proliferation [MESH] |*Epithelial-Mesenchymal Transition [MESH] |Aged [MESH] |Cataract/genetics/*metabolism/pathology [MESH] |Cell Line [MESH] |Epithelial Cells/*metabolism/pathology [MESH] |Female [MESH] |Humans [MESH] |Lens, Crystalline/*metabolism/pathology [MESH] |Male [MESH] |Middle Aged [MESH] |RNA, Long Noncoding/genetics/*metabolism [MESH]Long noncoding RNA KCNQ1OT1 promotes proliferation and epithelial?mese(epmc).pdf DeepDyve Pubget Overpricing