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10.1016/j.cyto.2016.06.017 http://scihub22266oqcxt.onion/10.1016/j.cyto.2016.06.017 C6059362!6059362!27349799     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cytokine 2016 ; 87 (ä): 26-36 Nephropedia Template TP {{tp|p=27349799|t=2016. JAK-STAT signaling in cancer: From cytokines to non-coding genome |pdf=|usr=}}{{27349799}} gab.com Text JAK-STAT signaling in cancer: From cytokines to non-coding genome JO: Cytokine http://www.kidney.de/pget.php?&tw=1&pmid=27349799 #FOAvip In the past decades, studies of the Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) signaling have uncovered highly conserved programs linking cytokine signaling to the regulation of essential cellular mechanisms such as proliferation, invasion, survival, inflammation and immunity. Inhibitors of the JAK/STAT pathway are used for treatment of autoimmune diseases, such as rheumatoid arthritis or psoriasis. Aberrant JAK/STAT signaling has been identified to contribute to cancer progression and metastatic development. Targeting of JAK/STAT pathway is currently one of the most promising therapeutic strategies in prostate cancer (PCa), hematopoietic malignancies and sarcomas. Notably, newly identified regulators of JAK/STAT signaling, the non-coding RNAs transcripts and their role as important targets and potential clinical biomarkers are highlighted in this review. In addition to the established role of the JAK/STAT signaling pathway in traditional cytokine signaling the non-coding RNAs add yet another layer of hidden regulation and function.Understanding the crosstalk of non-coding RNA with JAK/STAT signaling in cancer is of critical importance and may result in better patient stratification not only in terms of prognosis but also in the context of therapy. Twit Text FOAVip JAK-STAT signaling in cancer: From cytokines to non-coding genome ????Cytokine http://www.kidney.de/pget.php?&tw=1&pmid=27349799 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27349799 #FOAvip English Wikipedia <ref>{{Cite pmid|27349799}}</ref> JAK-STAT signaling in cancer: From cytokines to non-coding genome #MMPMID27349799 Pencik J; Pham HTT; Schmoellerl J; Javaheri T; Schlederer M; Culig Z; Merkel O; Moriggl R; Grebien F; Kenner L Cytokine 2016[Nov]; 87 (ä): 26-36 PMID27349799show ga In the past decades, studies of the Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) signaling have uncovered highly conserved programs linking cytokine signaling to the regulation of essential cellular mechanisms such as proliferation, invasion, survival, inflammation and immunity. Inhibitors of the JAK/STAT pathway are used for treatment of autoimmune diseases, such as rheumatoid arthritis or psoriasis. Aberrant JAK/STAT signaling has been identified to contribute to cancer progression and metastatic development. Targeting of JAK/STAT pathway is currently one of the most promising therapeutic strategies in prostate cancer (PCa), hematopoietic malignancies and sarcomas. Notably, newly identified regulators of JAK/STAT signaling, the non-coding RNAs transcripts and their role as important targets and potential clinical biomarkers are highlighted in this review. In addition to the established role of the JAK/STAT signaling pathway in traditional cytokine signaling the non-coding RNAs add yet another layer of hidden regulation and function.Understanding the crosstalk of non-coding RNA with JAK/STAT signaling in cancer is of critical importance and may result in better patient stratification not only in terms of prognosis but also in the context of therapy. äJAK-STAT signaling in cancer: From cytokines to non-coding genome (epmc).pdf DeepDyve Pubget Overpricing