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10.18632/oncotarget.25734 http://scihub22266oqcxt.onion/10.18632/oncotarget.25734 C6059023!6059023!30046396     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2018 ; 9 (53): 30173-88 Nephropedia Template TP {{tp|p=30046396|t=2018. Tumor endothelial marker 8 promotes cancer progression and metastasis |pdf=|usr=}}{{30046396}} gab.com Text Tumor endothelial marker 8 promotes cancer progression and metastasis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=30046396 #FOAvip Every year more than 8 million people suffer from cancer-related deaths worldwide [1]. Metastasis, the spread of cancer to distant sites, accounts for 90% of these deaths. A promising target for blocking tumor progression, without causing severe side effects [2], is Tumor Endothelial Marker 8 (TEM8), an integrin-like cell surface protein expressed predominantly in the tumor endothelium and in cancer cells [3, 4]. Here, we have investigated the role of TEM8 in cancer progression, angiogenesis and metastasis in invasive breast cancer, and validated the main findings and important results in colorectal cancer. We show that the loss of TEM8 in cancer cells results in inhibition of cancer progression, reduction in tumor angiogenesis and reduced metastatic burden in breast cancer mouse models. Furthermore, we show that TEM8 regulates cancer progression by affecting the expression levels of cell cycle-related genes. Taken together, our findings may have broad clinical and therapeutic potential for breast and colorectal primary tumor and metastasis treatment by targeting TEM8. Twit Text FOAVip Tumor endothelial marker 8 promotes cancer progression and metastasis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=30046396 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30046396 #FOAvip English Wikipedia <ref>{{Cite pmid|30046396}}</ref> Tumor endothelial marker 8 promotes cancer progression and metastasis #MMPMID30046396 Høye AM; Tolstrup SD; Horton ER; Nicolau M; Frost H; Woo JH; Mauldin JP; Frankel AE; Cox TR; Erler JT Oncotarget 2018[Jul]; 9 (53): 30173-88 PMID30046396show ga Every year more than 8 million people suffer from cancer-related deaths worldwide [1]. Metastasis, the spread of cancer to distant sites, accounts for 90% of these deaths. A promising target for blocking tumor progression, without causing severe side effects [2], is Tumor Endothelial Marker 8 (TEM8), an integrin-like cell surface protein expressed predominantly in the tumor endothelium and in cancer cells [3, 4]. Here, we have investigated the role of TEM8 in cancer progression, angiogenesis and metastasis in invasive breast cancer, and validated the main findings and important results in colorectal cancer. We show that the loss of TEM8 in cancer cells results in inhibition of cancer progression, reduction in tumor angiogenesis and reduced metastatic burden in breast cancer mouse models. Furthermore, we show that TEM8 regulates cancer progression by affecting the expression levels of cell cycle-related genes. Taken together, our findings may have broad clinical and therapeutic potential for breast and colorectal primary tumor and metastasis treatment by targeting TEM8. äTumor endothelial marker 8 promotes cancer progression and metastasis (epmc).pdf DeepDyve Pubget Overpricing