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10.1038/s41598-018-29391-w http://scihub22266oqcxt.onion/10.1038/s41598-018-29391-w C6057998!6057998 !30042514     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30042514 &cmd=llinks): Failed to open stream: HTTP request failed! 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Inhibition of Tunneling Nanotube (TNT) Formation and Human T-cell Leukemia Virus Type 1 (HTLV-1) Transmission by Cytarabine |pdf=|usr=}}{{30042514 }} gab.com Text Inhibition of Tunneling Nanotube (TNT) Formation and Human T-cell Leukemia Virus Type 1 (HTLV-1) Transmission by Cytarabine JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30042514 #FOAvip The human T-cell leukemia virus type 1 (HTLV-1) is highly dependent on cell-to-cell interaction for transmission and productive infection. Cell-to-cell interactions through the virological synapse, biofilm-like structures and cellular conduits have been reported, but the relative contribution of each mechanism on HTLV-1 transmission still remains vastly unknown. The HTLV-1 protein p8 has been found to increase viral transmission and cellular conduits. Here we show that HTLV-1 expressing cells are interconnected by tunneling nanotubes (TNTs) defined as thin structures containing F-actin and lack of tubulin connecting two cells. TNTs connected HTLV-1 expressing cells and uninfected T-cells and monocytes and the viral proteins Tax and Gag localized to these TNTs. The HTLV-1 expressing protein p8 was found to induce TNT formation. Treatment of MT-2 cells with the nucleoside analog cytarabine (cytosine arabinoside, AraC) reduced number of TNTs and furthermore reduced TNT formation induced by the p8 protein. Intercellular transmission of HTLV-1 through TNTs provides a means of escape from recognition by the immune system. Cytarabine could represent a novel anti-HTLV-1 drug interfering with viral transmission. Twit Text FOAVip Inhibition of Tunneling Nanotube (TNT) Formation and Human T-cell Leukemia Virus Type 1 (HTLV-1) Transmission by Cytarabine ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30042514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30042514 #FOAvip English Wikipedia <ref>{{Cite pmid|30042514 }}</ref> Inhibition of Tunneling Nanotube (TNT) Formation and Human T-cell Leukemia Virus Type 1 (HTLV-1) Transmission by Cytarabine #MMPMID30042514 Omsland M ; Pise-Masison C ; Fujikawa D ; Galli V ; Fenizia C ; Parks RW ; Gjertsen BT ; Franchini G ; Andresen V Sci Rep 2018[Jul]; 8 (1 ): 11118 PMID30042514 show ga The human T-cell leukemia virus type 1 (HTLV-1) is highly dependent on cell-to-cell interaction for transmission and productive infection. Cell-to-cell interactions through the virological synapse, biofilm-like structures and cellular conduits have been reported, but the relative contribution of each mechanism on HTLV-1 transmission still remains vastly unknown. The HTLV-1 protein p8 has been found to increase viral transmission and cellular conduits. Here we show that HTLV-1 expressing cells are interconnected by tunneling nanotubes (TNTs) defined as thin structures containing F-actin and lack of tubulin connecting two cells. TNTs connected HTLV-1 expressing cells and uninfected T-cells and monocytes and the viral proteins Tax and Gag localized to these TNTs. The HTLV-1 expressing protein p8 was found to induce TNT formation. Treatment of MT-2 cells with the nucleoside analog cytarabine (cytosine arabinoside, AraC) reduced number of TNTs and furthermore reduced TNT formation induced by the p8 protein. Intercellular transmission of HTLV-1 through TNTs provides a means of escape from recognition by the immune system. Cytarabine could represent a novel anti-HTLV-1 drug interfering with viral transmission. |Actin Cytoskeleton/drug effects [MESH] |Actins/genetics [MESH] |Cell Communication/*genetics/immunology [MESH] |Cytarabine/pharmacology [MESH] |Gene Products, tax/genetics [MESH] |HTLV-I Infections/*genetics/transmission/virology [MESH] |Human T-lymphotropic virus 1/drug effects/*genetics/pathogenicity [MESH] |Humans [MESH] |Immune System [MESH] |Jurkat Cells/virology [MESH] |Leukemia, T-Cell/genetics/pathology/virology [MESH] |Nanotubes/*chemistry [MESH] |T-Lymphocytes/immunology [MESH] |Tubulin/*genetics [MESH]Inhibition of Tunneling Nanotube (TNT) Formation and Human T-cell Leuk(epmc).pdf DeepDyve Pubget Overpricing