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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Mayo+Clin+Proc
2018 ; 93
(5
): 597-606
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gab.com Text
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English Wikipedia
Risk of Cardiovascular Disease and Venous Thromboembolism Among Patients With
Incident ANCA-Associated Vasculitis: A 20-Year Population-Based Cohort Study
#MMPMID29588079
Berti A
; Matteson EL
; Crowson CS
; Specks U
; Cornec D
Mayo Clin Proc
2018[May]; 93
(5
): 597-606
PMID29588079
show ga
OBJECTIVE: To assess the cardiovascular disease (CVD) and venous thromboembolism
(VTE) risks among patients with newly diagnosed antineutrophil cytoplasmic
antibodies (ANCA)-associated vasculitis (AAV). PATIENTS AND METHODS: A
population-based incident AAV cohort of 58 patients diagnosed between 1996 and
2015 in Olmsted County, MN, was identified by medical record review. For each
patient, 3 age- and sex-matched non-AAV comparators were randomly selected from
the same population and assigned an index date corresponding to the AAV incidence
date. Medical records of cases and comparators were reviewed for CVD events,
which included cardiac events (coronary artery disease, heart failure, and atrial
fibrillation), cerebrovascular accidents (CVA), peripheral vascular disease
(PVD), and VTE, which included deep vein thrombosis (DVT) and pulmonary embolism
(PE). RESULTS: Baseline total cholesterol, high-density lipoprotein, and current
smoking rate were lower in AAV than in comparators (P=.03, P=.01, and P=.04,
respectively), whereas other CVD risk factors and Framingham risk score were not
significantly different between the 2 groups. The CVD events developed in 13
patients and 17 comparators, corresponding to a more than 3-fold increased risk
(hazard ratio [HR], 3.15; 95% CI, 1.51-6.57). By subtypes, risks were increased
for cardiac events (HR, 2.96; 95% CI, 1.42-6.15) and CVA (HR, 8.16; 95% CI,
2.45-27.15), but not for PVD. The HR for VTE was 3.26 (95% CI, 0.84-12.60),
significantly increased for DVT (HR, 6.25; 95% CI, 1.16-33.60), but not for PE
(HR, 1.33; 95% CI, 0.23-7.54). CONCLUSION: Despite a similar prevalence of CVD
risk factors at baseline, the risk of CVD is more than 3-fold higher and for CVA
8-fold higher in patients with incident AAV than in matched comparator subjects.