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10.1093/ilar/ilw041 http://scihub22266oqcxt.onion/10.1093/ilar/ilw041 C6057551!6057551!28838068     free     free     free       ILAR+J 2017 ; 58 (1): 42-58 Nephropedia Template TP {{tp|p=28838068|t=2017. Rat Genome and Model Resources |pdf=|usr=}}{{28838068}} gab.com Text Rat Genome and Model Resources JO: ILAR J http://www.kidney.de/pget.php?&tw=1&pmid=28838068 #FOAvip Rats remain a major model for studying disease mechanisms and discovery, validation, and testing of new compounds to improve human health. The rat?s value continues to grow as indicated by the more than 1.4 million publications (second to human) at PubMed documenting important discoveries using this model. Advanced sequencing technologies, genome modification techniques, and the development of embryonic stem cell protocols ensure the rat remains an important mammalian model for disease studies. The 2004 release of the reference genome has been followed by the production of complete genomes for more than two dozen individual strains utilizing NextGen sequencing technologies; their analyses have identified over 80 million variants. This explosion in genomic data has been accompanied by the ability to selectively edit the rat genome, leading to hundreds of new strains through multiple technologies. A number of resources have been developed to provide investigators with access to precision rat models, comprehensive datasets, and sophisticated software tools necessary for their research. Those profiled here include the Rat Genome Database, PhenoGen, Gene Editing Rat Resource Center, Rat Resource and Research Center, and the National BioResource Project for the Rat in Japan. Twit Text FOAVip Rat Genome and Model Resources ????ILAR J http://www.kidney.de/pget.php?&tw=1&pmid=28838068 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28838068 #FOAvip English Wikipedia <ref>{{Cite pmid|28838068}}</ref> Rat Genome and Model Resources #MMPMID28838068 Shimoyama M; Smith JR; Bryda E; Kuramoto T; Saba L; Dwinell M ILAR J 2017[Jul]; 58 (1): 42-58 PMID28838068show ga Rats remain a major model for studying disease mechanisms and discovery, validation, and testing of new compounds to improve human health. The rat?s value continues to grow as indicated by the more than 1.4 million publications (second to human) at PubMed documenting important discoveries using this model. Advanced sequencing technologies, genome modification techniques, and the development of embryonic stem cell protocols ensure the rat remains an important mammalian model for disease studies. The 2004 release of the reference genome has been followed by the production of complete genomes for more than two dozen individual strains utilizing NextGen sequencing technologies; their analyses have identified over 80 million variants. This explosion in genomic data has been accompanied by the ability to selectively edit the rat genome, leading to hundreds of new strains through multiple technologies. A number of resources have been developed to provide investigators with access to precision rat models, comprehensive datasets, and sophisticated software tools necessary for their research. Those profiled here include the Rat Genome Database, PhenoGen, Gene Editing Rat Resource Center, Rat Resource and Research Center, and the National BioResource Project for the Rat in Japan. äRat Genome and Model Resources (epmc).pdf DeepDyve Pubget Overpricing