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10.1016/j.immuni.2018.06.007 http://scihub22266oqcxt.onion/10.1016/j.immuni.2018.06.007 C6057275!6057275!30005826     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2018 ; 49 (1): 120-133.e9 Nephropedia Template TP {{tp|p=30005826|t=2018. LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells |pdf=|usr=}}{{30005826}} gab.com Text LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=30005826 #FOAvip B lymphocytes can suppress immunity through interleukin (IL)-10 production in infectious, autoimmune, and malignant diseases. Here, we have identified a natural plasma cell subset that distinctively expresses the inhibitory receptor LAG-3 and mediates this function in vivo. These plasma cells also express the inhibitory receptors CD200, PD-L1, and PD-L2. They develop from various B cell subsets in a B cell receptor (BCR)-dependent manner independently of microbiota in naive mice. After challenge they upregulate IL-10 expression via a Toll-like receptor-driven mechanism within hours and without proliferating. This function is associated with a unique transcriptome and epigenome, including the lowest amount of DNA methylation at the Il10 locus compared to other B cell subsets. Their augmented accumulation in naive mutant mice with increased BCR signaling correlates with the inhibition of memory T cell formation and vaccine efficacy after challenge. These natural regulatory plasma cells may be of broad relevance for disease intervention. Twit Text FOAVip LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=30005826 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30005826 #FOAvip English Wikipedia <ref>{{Cite pmid|30005826}}</ref> LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells #MMPMID30005826 Lino AC; Dang VD; Lampropoulou V; Welle A; Joedicke J; Pohar J; Simon Q; Thalmensi J; Baures A; Flühler V; Sakwa I; Stervbo U; Ries S; Jouneau L; Boudinot P; Tsubata T; Adachi T; Hutloff A; Dörner T; Zimber-Strobl U; de Vos AF; Dahlke K; Loh G; Korniotis S; Goosmann C; Weill JC; Reynaud CA; Kaufmann SH; Walter J; Fillatreau S Immunity 2018[Jul]; 49 (1): 120-133.e9 PMID30005826show ga B lymphocytes can suppress immunity through interleukin (IL)-10 production in infectious, autoimmune, and malignant diseases. Here, we have identified a natural plasma cell subset that distinctively expresses the inhibitory receptor LAG-3 and mediates this function in vivo. These plasma cells also express the inhibitory receptors CD200, PD-L1, and PD-L2. They develop from various B cell subsets in a B cell receptor (BCR)-dependent manner independently of microbiota in naive mice. After challenge they upregulate IL-10 expression via a Toll-like receptor-driven mechanism within hours and without proliferating. This function is associated with a unique transcriptome and epigenome, including the lowest amount of DNA methylation at the Il10 locus compared to other B cell subsets. Their augmented accumulation in naive mutant mice with increased BCR signaling correlates with the inhibition of memory T cell formation and vaccine efficacy after challenge. These natural regulatory plasma cells may be of broad relevance for disease intervention. äLAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natu(epmc).pdf DeepDyve Pubget Overpricing