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10.12659/MSMBR.910338 http://scihub22266oqcxt.onion/10.12659/MSMBR.910338 C6057264!6057264 !29959310     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29959310 &cmd=llinks): Failed to open stream: HTTP request failed! 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Prophylactic Atrial Fibrillation Ablation in Atrial Flutter Patients without Atrial Fibrillation: A Meta-Analysis with Trial Sequential Analysis |pdf=|usr=}}{{29959310 }} gab.com Text Prophylactic Atrial Fibrillation Ablation in Atrial Flutter Patients without Atrial Fibrillation: A Meta-Analysis with Trial Sequential Analysis JO: Med Sci Monit Basic Res http://www.kidney.de/pget.php?&tw=1&pmid=29959310 #FOAvip BACKGROUND New-onset atrial fibrillation (AF) is common after atrial flutter (AFL) ablation, but it was unclear whether AF ablation could reduce the incidence of AF in AFL patients without AF history. The present meta-analysis was conducted to evaluate the benefit of prophylactic AF ablation in reducing the occurrence of AF in typical AFL patients. MATERIAL AND METHODS We systematically searched PubMed, EMBASE, and the Cochrane Library from inception to December 2017 for randomized controlled trials (RCTs) that assessed the efficacy of AF ablation in reducing the occurrence of AF in AFL patients without AF. Trial sequential analysis (TSA) was used to control random errors and calculate the required information size. RESULTS Four trials (n=357 patients) met the inclusion criteria and were included in our meta-analysis. The incidence of AF after AFL ablation was 46.4%. We observed that prophylactic AF ablation reduced the AF incidence compared with simple AFL ablation (26.1% versus 46.4%, RR: 0.57, 95% CIs: 0.42-0.76, P=0.0002) with a prolonged procedure duration (P<0.00001) and fluoroscopy time (P=0.004). Further TSA indicated that more RCTs were needed to reach more conclusive results. There was no significant difference in clinical complications (P=0.33) between the 2 groups. CONCLUSIONS This meta-analysis provides evidence that prophylactic AF ablation may be more effective than simple AFL ablation in reducing AF incidence after AFL ablation. Large prospective RCTs are warranted to confirm the benefit of prophylactic AF ablation in AFL patients without AF history. Twit Text FOAVip Prophylactic Atrial Fibrillation Ablation in Atrial Flutter Patients without Atrial Fibrillation: A Meta-Analysis with Trial Sequential Analysis ????Med Sci Monit Basic Res http://www.kidney.de/pget.php?&tw=1&pmid=29959310 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29959310 #FOAvip English Wikipedia <ref>{{Cite pmid|29959310 }}</ref> Prophylactic Atrial Fibrillation Ablation in Atrial Flutter Patients without Atrial Fibrillation: A Meta-Analysis with Trial Sequential Analysis #MMPMID29959310 Xie X ; Liu X ; Chen B ; Wang Q Med Sci Monit Basic Res 2018[Jun]; 24 (ä): 96-102 PMID29959310 show ga BACKGROUND New-onset atrial fibrillation (AF) is common after atrial flutter (AFL) ablation, but it was unclear whether AF ablation could reduce the incidence of AF in AFL patients without AF history. The present meta-analysis was conducted to evaluate the benefit of prophylactic AF ablation in reducing the occurrence of AF in typical AFL patients. MATERIAL AND METHODS We systematically searched PubMed, EMBASE, and the Cochrane Library from inception to December 2017 for randomized controlled trials (RCTs) that assessed the efficacy of AF ablation in reducing the occurrence of AF in AFL patients without AF. Trial sequential analysis (TSA) was used to control random errors and calculate the required information size. RESULTS Four trials (n=357 patients) met the inclusion criteria and were included in our meta-analysis. The incidence of AF after AFL ablation was 46.4%. We observed that prophylactic AF ablation reduced the AF incidence compared with simple AFL ablation (26.1% versus 46.4%, RR: 0.57, 95% CIs: 0.42-0.76, P=0.0002) with a prolonged procedure duration (P<0.00001) and fluoroscopy time (P=0.004). Further TSA indicated that more RCTs were needed to reach more conclusive results. There was no significant difference in clinical complications (P=0.33) between the 2 groups. CONCLUSIONS This meta-analysis provides evidence that prophylactic AF ablation may be more effective than simple AFL ablation in reducing AF incidence after AFL ablation. Large prospective RCTs are warranted to confirm the benefit of prophylactic AF ablation in AFL patients without AF history. |Ablation Techniques/*adverse effects/*methods [MESH] |Atrial Fibrillation/*prevention & control/surgery [MESH] |Atrial Flutter/complications/physiopathology [MESH] |Catheter Ablation/methods [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Humans [MESH] |Incidence [MESH] |Male [MESH] |Prophylactic Surgical Procedures/adverse effects/methods [MESH] |Prospective Studies [MESH] |Risk Factors [MESH]Prophylactic Atrial Fibrillation Ablation in Atrial Flutter Patients w(epmc).pdf DeepDyve Pubget Overpricing