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10.1146/annurev-immunol-042617-053158 http://scihub22266oqcxt.onion/10.1146/annurev-immunol-042617-053158 C6057146!6057146!29677475     free     free     free       Annu+Rev+Immunol 2018 ; 36 (ä): 783-812 Nephropedia Template TP {{tp|p=29677475|t=2018. Molecular and Functional Neuroscience in Immunity |pdf=|usr=}}{{29677475}} gab.com Text Molecular and Functional Neuroscience in Immunity JO: Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29677475 #FOAvip The nervous system regulates immunity and inflammation. The molecular detection of pathogen fragments, cytokines, and other immune molecules by sensory neurons generates immunoregulatory responses through efferent autonomic neuron signaling. The functional organization of this neural control is based on principles of reflex regulation. Reflexes involving the vagus nerve and other nerves have been therapeutically explored in models of inflammatory and autoimmune conditions, and recently in clinical settings. The brain integrates neuro-immune communication, and brain function is altered in diseases characterized by peripheral immune dysregulation and inflammation. Here we review the anatomical and molecular basis of the neural interface with immunity, focusing on peripheral neural control of immune functions and the role of the brain in the model of the immunological homunculus. Clinical advances stemming from this knowledge within the framework of bioelectronic medicine are also briefly outlined. Twit Text FOAVip Molecular and Functional Neuroscience in Immunity ????Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29677475 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29677475 #FOAvip English Wikipedia <ref>{{Cite pmid|29677475}}</ref> Molecular and Functional Neuroscience in Immunity #MMPMID29677475 Pavlov VA; Chavan SS; Tracey KJ Annu Rev Immunol 2018[Apr]; 36 (ä): 783-812 PMID29677475show ga The nervous system regulates immunity and inflammation. The molecular detection of pathogen fragments, cytokines, and other immune molecules by sensory neurons generates immunoregulatory responses through efferent autonomic neuron signaling. The functional organization of this neural control is based on principles of reflex regulation. Reflexes involving the vagus nerve and other nerves have been therapeutically explored in models of inflammatory and autoimmune conditions, and recently in clinical settings. The brain integrates neuro-immune communication, and brain function is altered in diseases characterized by peripheral immune dysregulation and inflammation. Here we review the anatomical and molecular basis of the neural interface with immunity, focusing on peripheral neural control of immune functions and the role of the brain in the model of the immunological homunculus. Clinical advances stemming from this knowledge within the framework of bioelectronic medicine are also briefly outlined. äMolecular and Functional Neuroscience in Immunity (epmc).pdf DeepDyve Pubget Overpricing