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10.3389/fnagi.2018.00210 http://scihub22266oqcxt.onion/10.3389/fnagi.2018.00210 C6057109!6057109!30065645     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Aging+Neurosci 2018 ; 10 (ä): ä Nephropedia Template TP {{tp|p=30065645|t=2018. Pericyte Structural Remodeling in Cerebrovascular Health and Homeostasis |pdf=|usr=}}{{30065645}} gab.com Text Pericyte Structural Remodeling in Cerebrovascular Health and Homeostasis JO: Front Aging Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=30065645 #FOAvip The biology of brain microvascular pericytes is an active area of research and discovery, as their interaction with the endothelium is critical for multiple aspects of cerebrovascular function. There is growing evidence that pericyte loss or dysfunction is involved in the pathogenesis of Alzheimer?s disease, vascular dementia, ischemic stroke and brain injury. However, strategies to mitigate or compensate for this loss remain limited. In this review, we highlight a novel finding that pericytes in the adult brain are structurally dynamic in vivo, and actively compensate for loss of endothelial coverage by extending their far-reaching processes to maintain contact with regions of exposed endothelium. Structural remodeling of pericytes may present an opportunity to foster pericyte-endothelial communication in the adult brain and should be explored as a potential means to counteract pericyte loss in dementia and cerebrovascular disease. We discuss the pathophysiological consequences of pericyte loss on capillary function, and the biochemical pathways that may control pericyte remodeling. We also offer guidance for observing pericytes in vivo, such that pericyte structural remodeling can be more broadly studied in mouse models of cerebrovascular disease. Twit Text FOAVip Pericyte Structural Remodeling in Cerebrovascular Health and Homeostasis ????Front Aging Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=30065645 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30065645 #FOAvip English Wikipedia <ref>{{Cite pmid|30065645}}</ref> Pericyte Structural Remodeling in Cerebrovascular Health and Homeostasis #MMPMID30065645 Berthiaume AA; Hartmann DA; Majesky MW; Bhat NR; Shih AY Front Aging Neurosci 2018[]; 10 (ä): ä PMID30065645show ga The biology of brain microvascular pericytes is an active area of research and discovery, as their interaction with the endothelium is critical for multiple aspects of cerebrovascular function. There is growing evidence that pericyte loss or dysfunction is involved in the pathogenesis of Alzheimer?s disease, vascular dementia, ischemic stroke and brain injury. However, strategies to mitigate or compensate for this loss remain limited. In this review, we highlight a novel finding that pericytes in the adult brain are structurally dynamic in vivo, and actively compensate for loss of endothelial coverage by extending their far-reaching processes to maintain contact with regions of exposed endothelium. Structural remodeling of pericytes may present an opportunity to foster pericyte-endothelial communication in the adult brain and should be explored as a potential means to counteract pericyte loss in dementia and cerebrovascular disease. We discuss the pathophysiological consequences of pericyte loss on capillary function, and the biochemical pathways that may control pericyte remodeling. We also offer guidance for observing pericytes in vivo, such that pericyte structural remodeling can be more broadly studied in mouse models of cerebrovascular disease. äPericyte Structural Remodeling in Cerebrovascular Health and Homeostas(epmc).pdf DeepDyve Pubget Overpricing