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10.1186/s13578-018-0242-2 http://scihub22266oqcxt.onion/10.1186/s13578-018-0242-2 C6056998!6056998!30062004     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Biosci 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=30062004|t=2018. Role of MCM2?7 protein phosphorylation in human cancer cells |pdf=|usr=}}{{30062004}} gab.com Text Role of MCM2 7 protein phosphorylation in human cancer cells JO: Cell Biosci http://www.kidney.de/pget.php?&tw=1&pmid=30062004 #FOAvip A heterohexameric complex composed of minichromosome maintenance protein 2?7 (MCM2?7), which acts as a key replicative enzyme in eukaryotes, is crucial for initiating DNA synthesis only once per cell cycle. The MCM complex remains inactive through the G1 phase, until the S phase, when it is activated to initiate replication. During the transition from the G1 to S phase, the MCM undergoes multisite phosphorylation, an important change that promotes subsequent assembly of other replisome members. Phosphorylation is crucial for the regulation of MCM activity and function. MCMs can be phosphorylated by multiple kinases and these phosphorylation events are involved not only in DNA replication but also cell cycle progression and checkpoint response. Dysfunctional phosphorylation of MCMs appears to correlate with the occurrence and development of cancers. In this review, we summarize the currently available data regarding the regulatory mechanisms and functional consequences of MCM phosphorylation and seek the probability that protein kinase inhibitor can be used therapeutically to target MCM phosphorylation in cancer. Twit Text FOAVip Role of MCM2 7 protein phosphorylation in human cancer cells ????Cell Biosci http://www.kidney.de/pget.php?&tw=1&pmid=30062004 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30062004 #FOAvip English Wikipedia <ref>{{Cite pmid|30062004}}</ref> Role of MCM2?7 protein phosphorylation in human cancer cells #MMPMID30062004 Fei L; Xu H Cell Biosci 2018[]; 8 (ä): ä PMID30062004show ga A heterohexameric complex composed of minichromosome maintenance protein 2?7 (MCM2?7), which acts as a key replicative enzyme in eukaryotes, is crucial for initiating DNA synthesis only once per cell cycle. The MCM complex remains inactive through the G1 phase, until the S phase, when it is activated to initiate replication. During the transition from the G1 to S phase, the MCM undergoes multisite phosphorylation, an important change that promotes subsequent assembly of other replisome members. Phosphorylation is crucial for the regulation of MCM activity and function. MCMs can be phosphorylated by multiple kinases and these phosphorylation events are involved not only in DNA replication but also cell cycle progression and checkpoint response. Dysfunctional phosphorylation of MCMs appears to correlate with the occurrence and development of cancers. In this review, we summarize the currently available data regarding the regulatory mechanisms and functional consequences of MCM phosphorylation and seek the probability that protein kinase inhibitor can be used therapeutically to target MCM phosphorylation in cancer. äRole of MCM2?7 protein phosphorylation in human cancer cells (epmc).pdf DeepDyve Pubget Overpricing