Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s12931-018-0841-9 http://scihub22266oqcxt.onion/10.1186/s12931-018-0841-9 C6056940!6056940!30041633     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Respir+Res 2018 ; 19 (ä): ä Nephropedia Template TP {{tp|p=30041633|t=2018. Human alveolar epithelial cells type II are capable of TGF?-dependent epithelial-mesenchymal-transition and collagen-synthesis |pdf=|usr=}}{{30041633}} gab.com Text Human alveolar epithelial cells type II are capable of TGF -dependent epithelial-mesenchymal-transition and collagen-synthesis JO: Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=30041633 #FOAvip Background: The origin of collagen-producing cells in lung fibrosis is unclear. The involvement of embryonic signaling pathways has been acknowledged and trans-differentiation of epithelial cells is discussed critically. The work presented here investigates the role of TGFB in cytoskeleton remodeling and the expression of Epithelial-Mesenchymal-Transition markers by Alveolar Epithelial Cells Type II and tests the hypothesis if human alveolar epithelial cells are capable of trans-differentiation and production of pro-fibrotic collagen. Methods: Primary human alveolar epithelial cells type II were extracted from donor tissues and stimulated with TGF? and a TGF?-inhibitor. Transcriptome and pathway analyses as well as validation of results on protein level were conducted. Results: A TGF?-responsive fingerprint was found and investigated for mutual interactions. Interaction modules exhibited enrichment of genes that favor actin cytoskeleton remodeling, differentiation processes and collagen metabolism. Cross-validation of the TGF?-responsive fingerprint in an independent IPF dataset revealed overlap of genes and supported the direction of regulated genes and TGF?-specificity. Conclusions: Primary human alveolar epithelial cells type II seem undergo a TGF?-dependent phenotypic change, exhibit differential expression of EMT markers in vitro and acquire the potential to produce collagen. Electronic supplementary material: The online version of this article (10.1186/s12931-018-0841-9) contains supplementary material, which is available to authorized users. Twit Text FOAVip Human alveolar epithelial cells type II are capable of TGF -dependent epithelial-mesenchymal-transition and collagen-synthesis ????Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=30041633 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30041633 #FOAvip English Wikipedia <ref>{{Cite pmid|30041633}}</ref> Human alveolar epithelial cells type II are capable of TGF?-dependent epithelial-mesenchymal-transition and collagen-synthesis #MMPMID30041633 Goldmann T; Zissel G; Watz H; Drömann D; Reck M; Kugler C; Rabe KF; Marwitz S Respir Res 2018[]; 19 (ä): ä PMID30041633show ga Background: The origin of collagen-producing cells in lung fibrosis is unclear. The involvement of embryonic signaling pathways has been acknowledged and trans-differentiation of epithelial cells is discussed critically. The work presented here investigates the role of TGFB in cytoskeleton remodeling and the expression of Epithelial-Mesenchymal-Transition markers by Alveolar Epithelial Cells Type II and tests the hypothesis if human alveolar epithelial cells are capable of trans-differentiation and production of pro-fibrotic collagen. Methods: Primary human alveolar epithelial cells type II were extracted from donor tissues and stimulated with TGF? and a TGF?-inhibitor. Transcriptome and pathway analyses as well as validation of results on protein level were conducted. Results: A TGF?-responsive fingerprint was found and investigated for mutual interactions. Interaction modules exhibited enrichment of genes that favor actin cytoskeleton remodeling, differentiation processes and collagen metabolism. Cross-validation of the TGF?-responsive fingerprint in an independent IPF dataset revealed overlap of genes and supported the direction of regulated genes and TGF?-specificity. Conclusions: Primary human alveolar epithelial cells type II seem undergo a TGF?-dependent phenotypic change, exhibit differential expression of EMT markers in vitro and acquire the potential to produce collagen. Electronic supplementary material: The online version of this article (10.1186/s12931-018-0841-9) contains supplementary material, which is available to authorized users. äHuman alveolar epithelial cells type II are capable of TGF?-dependent (epmc).pdf DeepDyve Pubget Overpricing