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Ultrastructural Characteristics of Neuronal Death and White Matter Injury in
Mouse Brain Tissues After Intracerebral Hemorrhage: Coexistence of Ferroptosis,
Autophagy, and Necrosis
#MMPMID30065697
Li Q
; Weiland A
; Chen X
; Lan X
; Han X
; Durham F
; Liu X
; Wan J
; Ziai WC
; Hanley DF
; Wang J
Front Neurol
2018[]; 9
(?): 581
PMID30065697
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Although intracerebral hemorrhage (ICH) is a devastating disease worldwide, the
pathologic changes in ultrastructure during the acute and chronic phases of ICH
are poorly described. In this study, transmission electron microscopy was used to
examine the ultrastructure of ICH-induced pathology. ICH was induced in mice by
an intrastriatal injection of collagenase. Pathologic changes were observed in
the acute (3 days), subacute (6 days), and chronic (28 days) phases. Compared
with sham animals, we observed various types of cell death in the injured
striatum during the acute phase of ICH, including necrosis, ferroptosis, and
autophagy. Different degrees of axon degeneration in the striatum were seen in
the acute phase, and axonal demyelination was observed in the ipsilateral
striatum and corpus callosum at late time points. In addition, phagocytes,
resident microglia, and infiltrating monocyte-macrophages were present around red
blood cells and degenerating neurons and were observed to engulf red blood cells
and other debris. Many synapses appeared abnormal or were lost. This systematic
analysis of the pathologic changes in ultrastructure after ICH in mice provides
information that will be valuable for future ICH pathology studies.
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