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10.1002/jcp.26634 http://scihub22266oqcxt.onion/10.1002/jcp.26634 C6055758!6055758!29744893     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Physiol 2018 ; 233 (10): 7113-27 Nephropedia Template TP {{tp|p=29744893|t=2018. Genome?wide binding of transcription factor ZEB1 in triple?negative breast cancer cells |pdf=|usr=}}{{29744893}} gab.com Text Genome wide binding of transcription factor ZEB1 in triple negative breast cancer cells JO: J Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=29744893 #FOAvip Zinc finger E?box binding homeobox 1 (ZEB1) is a transcriptional regulator involved in embryonic development and cancer progression. ZEB1 induces epithelial?mesenchymal transition (EMT). Triple?negative human breast cancers express high ZEB1 mRNA levels and exhibit features of EMT. In the human triple?negative breast cancer cell model Hs578T, ZEB1 associates with almost 2,000 genes, representing many cellular functions, including cell polarity regulation (DLG2 and FAT3). By introducing a CRISPR?Cas9?mediated 30?bp deletion into the ZEB1 second exon, we observed reduced migratory and anchorage?independent growth capacity of these tumor cells. Transcriptomic analysis of control and ZEB1 knockout cells, revealed 1,372 differentially expressed genes. The TIMP metallopeptidase inhibitor 3 and the teneurin transmembrane protein 2 genes showed increased expression upon loss of ZEB1, possibly mediating pro?tumorigenic actions of ZEB1. This work provides a resource for regulators of cancer progression that function under the transcriptional control of ZEB1. The data confirm that removing a single EMT transcription factor, such as ZEB1, is not sufficient for reverting the triple?negative mesenchymal breast cancer cells into more differentiated, epithelial?like clones, but can reduce tumorigenic potential, suggesting that not all pro?tumorigenic actions of ZEB1 are linked to the EMT. Twit Text FOAVip Genome wide binding of transcription factor ZEB1 in triple negative breast cancer cells ????J Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=29744893 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29744893 #FOAvip English Wikipedia <ref>{{Cite pmid|29744893}}</ref> Genome?wide binding of transcription factor ZEB1 in triple?negative breast cancer cells #MMPMID29744893 Maturi V; Enroth S; Heldin C; Moustakas A J Cell Physiol 2018[Oct]; 233 (10): 7113-27 PMID29744893show ga Zinc finger E?box binding homeobox 1 (ZEB1) is a transcriptional regulator involved in embryonic development and cancer progression. ZEB1 induces epithelial?mesenchymal transition (EMT). Triple?negative human breast cancers express high ZEB1 mRNA levels and exhibit features of EMT. In the human triple?negative breast cancer cell model Hs578T, ZEB1 associates with almost 2,000 genes, representing many cellular functions, including cell polarity regulation (DLG2 and FAT3). By introducing a CRISPR?Cas9?mediated 30?bp deletion into the ZEB1 second exon, we observed reduced migratory and anchorage?independent growth capacity of these tumor cells. Transcriptomic analysis of control and ZEB1 knockout cells, revealed 1,372 differentially expressed genes. The TIMP metallopeptidase inhibitor 3 and the teneurin transmembrane protein 2 genes showed increased expression upon loss of ZEB1, possibly mediating pro?tumorigenic actions of ZEB1. This work provides a resource for regulators of cancer progression that function under the transcriptional control of ZEB1. The data confirm that removing a single EMT transcription factor, such as ZEB1, is not sufficient for reverting the triple?negative mesenchymal breast cancer cells into more differentiated, epithelial?like clones, but can reduce tumorigenic potential, suggesting that not all pro?tumorigenic actions of ZEB1 are linked to the EMT. äGenome?wide binding of transcription factor ZEB1 in triple?negative br(epmc).pdf DeepDyve Pubget Overpricing