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10.1002/eji.201747372 http://scihub22266oqcxt.onion/10.1002/eji.201747372 C6055716!6055716!29676785     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2018 ; 48 (7): 1164-73 Nephropedia Template TP {{tp|p=29676785|t=2018. Sustained cross?presentation capacity of murine splenic dendritic cell subsets in vivo |pdf=|usr=}}{{29676785}} gab.com Text Sustained cross presentation capacity of murine splenic dendritic cell subsets in vivo JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29676785 #FOAvip An exclusive feature of dendritic cells (DCs) is their ability to cross?present exogenous antigens in MHC class I molecules. We analyzed the fate of protein antigen in antigen presenting cell (APC) subsets after uptake of naturally formed antigen?antibody complexes in vivo. We observed that murine splenic DC subsets were able to present antigen in vivo for at least a week. After ex vivo isolation of four APC subsets, the presence of antigen in the storage compartments was visualized by confocal microscopy. Although all APC subsets stored antigen for many days, their ability and kinetics in antigen presentation was remarkably different. CD8?+ DCs showed sustained MHC class I?peptide specific CD8+ T?cell activation for more than 4 days. CD8?? DCs also presented antigenic peptides in MHC class I but presentation decreased after 48 h. In contrast, only the CD8?? DCs were able to present antigen in MHC class II to specific CD4+ T cells. Plasmacytoid DCs and macrophages were unable to activate any of the two T?cell types despite detectable antigen uptake. These results indicate that naturally occurring DC subsets have functional antigen storage capacity for prolonged T?cell activation and have distinct roles in antigen presentation to specific T cells in vivo. Twit Text FOAVip Sustained cross presentation capacity of murine splenic dendritic cell subsets in vivo ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29676785 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29676785 #FOAvip English Wikipedia <ref>{{Cite pmid|29676785}}</ref> Sustained cross?presentation capacity of murine splenic dendritic cell subsets in vivo #MMPMID29676785 Ho NI; Camps MGM; de Haas EFE; Ossendorp F Eur J Immunol 2018[Jul]; 48 (7): 1164-73 PMID29676785show ga An exclusive feature of dendritic cells (DCs) is their ability to cross?present exogenous antigens in MHC class I molecules. We analyzed the fate of protein antigen in antigen presenting cell (APC) subsets after uptake of naturally formed antigen?antibody complexes in vivo. We observed that murine splenic DC subsets were able to present antigen in vivo for at least a week. After ex vivo isolation of four APC subsets, the presence of antigen in the storage compartments was visualized by confocal microscopy. Although all APC subsets stored antigen for many days, their ability and kinetics in antigen presentation was remarkably different. CD8?+ DCs showed sustained MHC class I?peptide specific CD8+ T?cell activation for more than 4 days. CD8?? DCs also presented antigenic peptides in MHC class I but presentation decreased after 48 h. In contrast, only the CD8?? DCs were able to present antigen in MHC class II to specific CD4+ T cells. Plasmacytoid DCs and macrophages were unable to activate any of the two T?cell types despite detectable antigen uptake. These results indicate that naturally occurring DC subsets have functional antigen storage capacity for prolonged T?cell activation and have distinct roles in antigen presentation to specific T cells in vivo. äSustained cross?presentation capacity of murine splenic dendritic cell(epmc).pdf DeepDyve Pubget Overpricing