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10.1111/ajt.14721 http://scihub22266oqcxt.onion/10.1111/ajt.14721 C6055714!6055714 !29509295     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29509295 &cmd=llinks): Failed to open stream: HTTP request failed! 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De novo donor-specific antibodies in belatacept-treated vs cyclosporine-treated kidney-transplant recipients: Post hoc analyses of the randomized phase III BENEFIT and BENEFIT-EXT studies |pdf=|usr=}}{{29509295 }} gab.com Text De novo donor-specific antibodies in belatacept-treated vs cyclosporine-treated kidney-transplant recipients: Post hoc analyses of the randomized phase III BENEFIT and BENEFIT-EXT studies JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=29509295 #FOAvip Donor-specific antibodies (DSAs) are associated with an increased risk of antibody-mediated rejection and graft failure. In BENEFIT and BENEFIT-EXT, kidney-transplant recipients were randomized to receive belatacept more intense (MI)-based, belatacept less intense (LI)-based, or cyclosporine-based immunosuppression for up to 7 years (84 months). The presence/absence of HLA-specific antibodies was determined at baseline, at months 6, 12, 24, 36, 48, 60, and 84, and at the time of clinically suspected episodes of acute rejection, using solid-phase flow-cytometry screening. Samples from anti-HLA-positive patients were further tested with a single-antigen bead assay to determine antibody specificities, presence/absence of DSAs, and mean fluorescence intensity (MFI) of any DSAs present. In BENEFIT, de novo DSAs developed in 1.4%, 3.5%, and 12.1% of belatacept MI-treated, belatacept LI-treated, and cyclosporine-treated patients, respectively. The corresponding values in BENEFIT-EXT were 3.8%, 1.1%, and 11.2%. Per Kaplan-Meier analysis, de novo DSA incidence was significantly lower in belatacept-treated vs cyclosporine-treated patients over 7 years in both studies (P < .01). In patients who developed de novo DSAs, belatacept-based immunosuppression was associated with numerically lower MFI vs cyclosporine-based immunosuppression. Although derived post hoc, these data suggest that belatacept-based immunosuppression suppresses de novo DSA development more effectively than cyclosporine-based immunosuppression. Twit Text FOAVip De novo donor-specific antibodies in belatacept-treated vs cyclosporine-treated kidney-transplant recipients: Post hoc analyses of the randomized phase III BENEFIT and BENEFIT-EXT studies ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=29509295 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29509295 #FOAvip English Wikipedia <ref>{{Cite pmid|29509295 }}</ref> De novo donor-specific antibodies in belatacept-treated vs cyclosporine-treated kidney-transplant recipients: Post hoc analyses of the randomized phase III BENEFIT and BENEFIT-EXT studies #MMPMID29509295 Bray RA ; Gebel HM ; Townsend R ; Roberts ME ; Polinsky M ; Yang L ; Meier-Kriesche HU ; Larsen CP Am J Transplant 2018[Jul]; 18 (7 ): 1783-1789 PMID29509295 show ga Donor-specific antibodies (DSAs) are associated with an increased risk of antibody-mediated rejection and graft failure. In BENEFIT and BENEFIT-EXT, kidney-transplant recipients were randomized to receive belatacept more intense (MI)-based, belatacept less intense (LI)-based, or cyclosporine-based immunosuppression for up to 7 years (84 months). The presence/absence of HLA-specific antibodies was determined at baseline, at months 6, 12, 24, 36, 48, 60, and 84, and at the time of clinically suspected episodes of acute rejection, using solid-phase flow-cytometry screening. Samples from anti-HLA-positive patients were further tested with a single-antigen bead assay to determine antibody specificities, presence/absence of DSAs, and mean fluorescence intensity (MFI) of any DSAs present. In BENEFIT, de novo DSAs developed in 1.4%, 3.5%, and 12.1% of belatacept MI-treated, belatacept LI-treated, and cyclosporine-treated patients, respectively. The corresponding values in BENEFIT-EXT were 3.8%, 1.1%, and 11.2%. Per Kaplan-Meier analysis, de novo DSA incidence was significantly lower in belatacept-treated vs cyclosporine-treated patients over 7 years in both studies (P < .01). In patients who developed de novo DSAs, belatacept-based immunosuppression was associated with numerically lower MFI vs cyclosporine-based immunosuppression. Although derived post hoc, these data suggest that belatacept-based immunosuppression suppresses de novo DSA development more effectively than cyclosporine-based immunosuppression. |*Tissue Donors [MESH] |Abatacept/*therapeutic use [MESH] |Adult [MESH] |Cyclosporine/*therapeutic use [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Graft Rejection/blood/*drug therapy/etiology [MESH] |Graft Survival/immunology [MESH] |Humans [MESH] |Immune Tolerance/immunology [MESH] |Immunosuppressive Agents/therapeutic use [MESH] |International Agencies [MESH] |Isoantibodies/*blood/immunology [MESH] |Kidney Failure, Chronic/*surgery [MESH] |Kidney Transplantation/*adverse effects [MESH] |Male [MESH] |Middle Aged [MESH] |Postoperative Complications [MESH] |Prognosis [MESH] |Risk Factors [MESH]De novo donor-specific antibodies in belatacept-treated vs cyclosporin(epmc).pdf DeepDyve Pubget Overpricing