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10.1111/imcb.12020 http://scihub22266oqcxt.onion/10.1111/imcb.12020 C6055666!6055666!29423939     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunol+Cell+Biol 2018 ; 96 (6): 666-74 Nephropedia Template TP {{tp|p=29423939|t=2018. Human MAIT cells show metabolic quiescence with rapid glucose?dependent upregulation of granzyme B upon stimulation |pdf=|usr=}}{{29423939}} gab.com Text Human MAIT cells show metabolic quiescence with rapid glucose dependent upregulation of granzyme B upon stimulation JO: Immunol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=29423939 #FOAvip Mucosal?associated invariant T (MAIT) cells are a well?characterized innate?like T cell population abundant in the human liver, peripheral tissues and blood. MAIT cells serve in the first line of defense against infections, through engagement of their T cell receptor, which recognizes microbial metabolites presented on MR1, and through cytokine?mediated triggering. Typically, they show a quiescent memory phenotype but can undergo rapid upregulation of effector functions including cytolysis upon stimulation. T cells profoundly change their cellular metabolism during their maturation and activation. We sought to determine how MAIT cell metabolism may facilitate both the long?term memory phase in tissue and the transition to rapid effector function. Here, we show, by flow cytometric metabolism assays and extracellular flux analysis that, despite an effector?memory profile, human MAIT cells are metabolically quiescent in a resting state comparable to naïve and central memory T cells. Upon stimulation, they rapidly increase uptake of glucose and show a concomitant upregulation of the effector molecules notably granzyme B, which is impaired by inhibition of glycolysis with 2?deoxyglucose. These findings suggest that MAIT cells share some metabolic characteristics of both resting and effector T cell subsets, with a rapid transition upon triggering. Metabolic programming of this cell type may be of interest in understanding and modulating their function in infectious diseases and cancer. Twit Text FOAVip Human MAIT cells show metabolic quiescence with rapid glucose dependent upregulation of granzyme B upon stimulation ????Immunol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=29423939 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29423939 #FOAvip English Wikipedia <ref>{{Cite pmid|29423939}}</ref> Human MAIT cells show metabolic quiescence with rapid glucose?dependent upregulation of granzyme B upon stimulation #MMPMID29423939 Zinser ME; Highton AJ; Kurioka A; Kronsteiner B; Hagel J; Leng T; Marchi E; Phetsouphanh C; Willberg CB; Dunachie SJ; Klenerman P Immunol Cell Biol 2018[Jul]; 96 (6): 666-74 PMID29423939show ga Mucosal?associated invariant T (MAIT) cells are a well?characterized innate?like T cell population abundant in the human liver, peripheral tissues and blood. MAIT cells serve in the first line of defense against infections, through engagement of their T cell receptor, which recognizes microbial metabolites presented on MR1, and through cytokine?mediated triggering. Typically, they show a quiescent memory phenotype but can undergo rapid upregulation of effector functions including cytolysis upon stimulation. T cells profoundly change their cellular metabolism during their maturation and activation. We sought to determine how MAIT cell metabolism may facilitate both the long?term memory phase in tissue and the transition to rapid effector function. Here, we show, by flow cytometric metabolism assays and extracellular flux analysis that, despite an effector?memory profile, human MAIT cells are metabolically quiescent in a resting state comparable to naïve and central memory T cells. Upon stimulation, they rapidly increase uptake of glucose and show a concomitant upregulation of the effector molecules notably granzyme B, which is impaired by inhibition of glycolysis with 2?deoxyglucose. These findings suggest that MAIT cells share some metabolic characteristics of both resting and effector T cell subsets, with a rapid transition upon triggering. Metabolic programming of this cell type may be of interest in understanding and modulating their function in infectious diseases and cancer. äHuman MAIT cells show metabolic quiescence with rapid glucose?dependen(epmc).pdf DeepDyve Pubget Overpricing