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10.1002/ijc.31355 http://scihub22266oqcxt.onion/10.1002/ijc.31355 C6055653!6055653!29508386     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Cancer 2018 ; 143 (4): 958-70 Nephropedia Template TP {{tp|p=29508386|t=2018. Bepridil exhibits anti?leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia |pdf=|usr=}}{{29508386}} gab.com Text Bepridil exhibits anti leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia JO: Int J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29508386 #FOAvip Dysregulated NOTCH1 signaling, by either gene mutations or microenvironment interactions, has been increasingly linked to chronic lymphocytic leukemia (CLL). Thus, inhibiting NOTCH1 activity represents a potential therapeutic opportunity for this disease. Using gene expression?based screening, we identified the calcium channel modulator bepridil as a new NOTCH1 pathway inhibitor. In primary CLL cells, bepridil induced selective apoptosis even in the presence of the protective stroma. Cytotoxic effects of bepridil were independent of NOTCH1 mutation and other prognostic markers. The antitumor efficacy of bepridil was associated with inhibition of NOTCH1 activity through a decrement in trans?membrane and activated NOTCH1 protein levels with unchanged NOTCH2 protein levels. In a CLL xenotransplant model, bepridil significantly reduced the percentage of leukemic cells infiltrating the spleen via enhanced apoptosis and decreased NOTCH1 activation. In conclusion, we report in vitro and in vivo anti?leukemic activity of bepridil associated with inhibition of the NOTCH1 pathway in CLL. These data provide a rationale for the clinical development of bepridil as anti?NOTCH1 targeted therapy for CLL patients. Twit Text FOAVip Bepridil exhibits anti leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia ????Int J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29508386 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29508386 #FOAvip English Wikipedia <ref>{{Cite pmid|29508386}}</ref> Bepridil exhibits anti?leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia #MMPMID29508386 Baldoni S; Del Papa B; Dorillo E; Aureli P; De Falco F; Rompietti C; Sorcini D; Varasano E; Cecchini D; Zei T; Di Tommaso A; Rosati E; Alexe G; Roti G; Stegmaier K; Di Ianni M; Falzetti F; Sportoletti P Int J Cancer 2018[Aug]; 143 (4): 958-70 PMID29508386show ga Dysregulated NOTCH1 signaling, by either gene mutations or microenvironment interactions, has been increasingly linked to chronic lymphocytic leukemia (CLL). Thus, inhibiting NOTCH1 activity represents a potential therapeutic opportunity for this disease. Using gene expression?based screening, we identified the calcium channel modulator bepridil as a new NOTCH1 pathway inhibitor. In primary CLL cells, bepridil induced selective apoptosis even in the presence of the protective stroma. Cytotoxic effects of bepridil were independent of NOTCH1 mutation and other prognostic markers. The antitumor efficacy of bepridil was associated with inhibition of NOTCH1 activity through a decrement in trans?membrane and activated NOTCH1 protein levels with unchanged NOTCH2 protein levels. In a CLL xenotransplant model, bepridil significantly reduced the percentage of leukemic cells infiltrating the spleen via enhanced apoptosis and decreased NOTCH1 activation. In conclusion, we report in vitro and in vivo anti?leukemic activity of bepridil associated with inhibition of the NOTCH1 pathway in CLL. These data provide a rationale for the clinical development of bepridil as anti?NOTCH1 targeted therapy for CLL patients. äBepridil exhibits anti?leukemic activity associated with NOTCH1 pathwa(epmc).pdf DeepDyve Pubget Overpricing