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10.1111/jth.14136 http://scihub22266oqcxt.onion/10.1111/jth.14136 C6055612!6055612!29729651     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Thromb+Haemost 2018 ; 16 (7): 1413-22 Nephropedia Template TP {{tp|p=29729651|t=2018. Role of von Willebrand factor and ADAMTS?13 in early brain injury after experimental subarachnoid hemorrhage |pdf=|usr=}}{{29729651}} gab.com Text Role of von Willebrand factor and ADAMTS 13 in early brain injury after experimental subarachnoid hemorrhage JO: J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=29729651 #FOAvip Essentials: von Willebrand Factor (VWF) and ADAMTS13 may affect early injury after subarachnoid hemorrhage (SAH).Early brain injury was assessed in VWF?/?, ADAMTS13?/? and recombinant (r) ADAMTS13 treated mice.VWF?/? and rADAMTS13 treated mice had less brain injury than ADAMTS13?/? and wild?type mice.Early administration of rADAMTS13 may improve outcome after SAH by reducing early brain injury. Summary: Background: Early brain injury is an important determinant of poor functional outcome and case fatality after aneurysmal subarachnoid hemorrhage (SAH), and is associated with early platelet aggregation. No treatment exists for early brain injury after SAH. We investigated whether von Willebrand factor (VWF) is involved in the pathogenesis of early brain injury, and whether ultra?early treatment with recombinant ADAMTS?13 (rADAMTS?13) reduces early brain injury after experimental SAH. Methods: Experimental SAH in mice was induced by prechiasmatic injection of non?anticoagulated blood from a littermate. The following experimental SAH groups were investigated: C57BL/6J control (n = 21), VWF?/? (n = 25), ADAMTS?13?/? (n = 23), and C57BL/6J treated with rADAMTS?13 (n = 26). Mice were killed at 2 h after SAH. Primary outcome measures were microglial activation (IBA?1 surface area) and neuronal injury (number of cleaved caspase?3?positive neurons). Results: As compared with controls, microglial activation was decreased in VWF?/? mice (mean difference of ? 20.0%, 95% confidence interval [CI] ? 4.0% to ? 38.6%), increased in ADAMTS?13?/? mice (mean difference of + 34.0%, 95% CI 16.2?51.7%), and decreased in rADAMTS?13?treated mice (mean difference of ? 22.1%, 95% CI ? 3.4% to ? 39.1%). As compared with controls (185 neurons, interquartile range [IQR] 133?353), neuronal injury in the cerebral cortex was decreased in VWF?/? mice (63 neurons, IQR 25?78), not changed in ADAMTS?13?/? mice (53 neurons, IQR 26?221), and reduced in rADAMTS?13?treated mice (45 neurons, IQR 9?115). Conclusions: Our findings suggest that VWF is involved in the pathogenesis of early brain injury, and support the further study of rADAMTS?13 as a treatment option for early brain injury after SAH. Twit Text FOAVip Role of von Willebrand factor and ADAMTS 13 in early brain injury after experimental subarachnoid hemorrhage ????J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=29729651 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29729651 #FOAvip English Wikipedia <ref>{{Cite pmid|29729651}}</ref> Role of von Willebrand factor and ADAMTS?13 in early brain injury after experimental subarachnoid hemorrhage #MMPMID29729651 Wan H; Wang Y; Ai J; Brathwaite S; Ni H; Macdonald R; Hol E; Meijers J; Vergouwen M J Thromb Haemost 2018[Jul]; 16 (7): 1413-22 PMID29729651show ga Essentials: von Willebrand Factor (VWF) and ADAMTS13 may affect early injury after subarachnoid hemorrhage (SAH).Early brain injury was assessed in VWF?/?, ADAMTS13?/? and recombinant (r) ADAMTS13 treated mice.VWF?/? and rADAMTS13 treated mice had less brain injury than ADAMTS13?/? and wild?type mice.Early administration of rADAMTS13 may improve outcome after SAH by reducing early brain injury. Summary: Background: Early brain injury is an important determinant of poor functional outcome and case fatality after aneurysmal subarachnoid hemorrhage (SAH), and is associated with early platelet aggregation. No treatment exists for early brain injury after SAH. We investigated whether von Willebrand factor (VWF) is involved in the pathogenesis of early brain injury, and whether ultra?early treatment with recombinant ADAMTS?13 (rADAMTS?13) reduces early brain injury after experimental SAH. Methods: Experimental SAH in mice was induced by prechiasmatic injection of non?anticoagulated blood from a littermate. The following experimental SAH groups were investigated: C57BL/6J control (n = 21), VWF?/? (n = 25), ADAMTS?13?/? (n = 23), and C57BL/6J treated with rADAMTS?13 (n = 26). Mice were killed at 2 h after SAH. Primary outcome measures were microglial activation (IBA?1 surface area) and neuronal injury (number of cleaved caspase?3?positive neurons). Results: As compared with controls, microglial activation was decreased in VWF?/? mice (mean difference of ? 20.0%, 95% confidence interval [CI] ? 4.0% to ? 38.6%), increased in ADAMTS?13?/? mice (mean difference of + 34.0%, 95% CI 16.2?51.7%), and decreased in rADAMTS?13?treated mice (mean difference of ? 22.1%, 95% CI ? 3.4% to ? 39.1%). As compared with controls (185 neurons, interquartile range [IQR] 133?353), neuronal injury in the cerebral cortex was decreased in VWF?/? mice (63 neurons, IQR 25?78), not changed in ADAMTS?13?/? mice (53 neurons, IQR 26?221), and reduced in rADAMTS?13?treated mice (45 neurons, IQR 9?115). Conclusions: Our findings suggest that VWF is involved in the pathogenesis of early brain injury, and support the further study of rADAMTS?13 as a treatment option for early brain injury after SAH. äRole of von Willebrand factor and ADAMTS?13 in early brain injury afte(epmc).pdf DeepDyve Pubget Overpricing