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10.1002/rth2.12076 http://scihub22266oqcxt.onion/10.1002/rth2.12076 C6055497!6055497 !30046730     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30046730 &cmd=llinks): Failed to open stream: HTTP request failed! 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Perioperative interruption of direct oral anticoagulants in patients with atrial fibrillation: A systematic review and meta-analysis |pdf=|usr=}}{{30046730 }} gab.com Text Perioperative interruption of direct oral anticoagulants in patients with atrial fibrillation: A systematic review and meta-analysis JO: Res Pract Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=30046730 #FOAvip BACKGROUND: Patients with atrial fibrillation (AF) frequently undergo invasive procedures that require temporary interruption of anticoagulation. There is little evidence to guide the perioperative interruption of direct oral anticoagulants (DOACs). METHODS: A systematic literature search including studies that evaluated the perioperative interruption of DOACs for non-emergent invasive procedures in patients with AF was performed. The primary outcomes of interest were the 30-day risk of thromboembolic events and major bleeding. Secondary outcomes of interest included the 30-day risk of minor bleeding and overall mortality. The systematic review protocol and search strategy were registered online (PROSPERO January 27th 2017:CRD42017056124). RESULTS: A total of 8 publications encompassing 14 446 patients and 17 107 periprocedural interruptions were included in our study. Our analysis revealed a pooled postoperative 30-day thromboembolic complication risk of 0.41% (95% CI 0.29- 0.54), and a pooled 30-day postoperative major bleeding risk of 1.81% (95% CI 0.84-3.13). Pooled 30-day postoperative risks of minor bleeding and overall mortality were 3.08% (95% CI 1.02-6.20) and 0.67% (95% CI 0.29-1.23), respectively. Meta-analysis of the included comparative studies did not reveal any significant differences in these postoperative outcomes following the perioperative interruption of DOACs or vitamin K antagonists. CONCLUSIONS: The perioperative interruption of DOACs in patients with AF was associated with 0.4% thromboembolic and 1.8% major bleeding events at 30 days post surgery. These findings seem reassuring, but require validation in large prospective management studies where pre-operative DOAC levels are measured and compared with clinical outcomes in this patient population. Twit Text FOAVip Perioperative interruption of direct oral anticoagulants in patients with atrial fibrillation: A systematic review and meta-analysis ????Res Pract Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=30046730 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30046730 #FOAvip English Wikipedia <ref>{{Cite pmid|30046730 }}</ref> Perioperative interruption of direct oral anticoagulants in patients with atrial fibrillation: A systematic review and meta-analysis #MMPMID30046730 Shaw JR ; Woodfine JD ; Douketis J ; Schulman S ; Carrier M Res Pract Thromb Haemost 2018[Apr]; 2 (2 ): 282-290 PMID30046730 show ga BACKGROUND: Patients with atrial fibrillation (AF) frequently undergo invasive procedures that require temporary interruption of anticoagulation. There is little evidence to guide the perioperative interruption of direct oral anticoagulants (DOACs). METHODS: A systematic literature search including studies that evaluated the perioperative interruption of DOACs for non-emergent invasive procedures in patients with AF was performed. The primary outcomes of interest were the 30-day risk of thromboembolic events and major bleeding. Secondary outcomes of interest included the 30-day risk of minor bleeding and overall mortality. The systematic review protocol and search strategy were registered online (PROSPERO January 27th 2017:CRD42017056124). RESULTS: A total of 8 publications encompassing 14 446 patients and 17 107 periprocedural interruptions were included in our study. Our analysis revealed a pooled postoperative 30-day thromboembolic complication risk of 0.41% (95% CI 0.29- 0.54), and a pooled 30-day postoperative major bleeding risk of 1.81% (95% CI 0.84-3.13). Pooled 30-day postoperative risks of minor bleeding and overall mortality were 3.08% (95% CI 1.02-6.20) and 0.67% (95% CI 0.29-1.23), respectively. Meta-analysis of the included comparative studies did not reveal any significant differences in these postoperative outcomes following the perioperative interruption of DOACs or vitamin K antagonists. CONCLUSIONS: The perioperative interruption of DOACs in patients with AF was associated with 0.4% thromboembolic and 1.8% major bleeding events at 30 days post surgery. These findings seem reassuring, but require validation in large prospective management studies where pre-operative DOAC levels are measured and compared with clinical outcomes in this patient population. äPerioperative interruption of direct oral anticoagulants in patients w(epmc).pdf DeepDyve Pubget Overpricing