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10.1126/science.aan3269 http://scihub22266oqcxt.onion/10.1126/science.aan3269 C6055228!6055228!28860207     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2017 ; 357 (6357): 1294-8 Nephropedia Template TP {{tp|p=28860207|t=2017. PAF1 Regulation of Promoter-Proximal Pause Release via Enhancer Activation |pdf=|usr=}}{{28860207}} gab.com Text PAF1 Regulation of Promoter-Proximal Pause Release via Enhancer Activation JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=28860207 #FOAvip Gene expression in metazoans is regulated by RNA Polymerase II (Pol II) promoter-proximal pausing and its release. Previously, we identified that Pol II-associated factor 1 (PAF1) modulates the release of paused Pol II into productive elongation. Here, we find that PAF1 occupies transcriptional enhancers and restrains hyperactivation of a subset of these enhancers. Enhancer activation as the result of PAF1 loss releases Pol II from paused promoters of nearby PAF1 target genes. Knockout of PAF1-regulated enhancers attenuates the release of paused Pol II on PAF1 target genes without major interference in the establishment of pausing at their cognate promoters. Thus, a subset of enhancers can primarily modulate gene expression by controlling the release of paused Pol II in a PAF1-dependent manner. Twit Text FOAVip PAF1 Regulation of Promoter-Proximal Pause Release via Enhancer Activation ????Science http://www.kidney.de/pget.php?&tw=1&pmid=28860207 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28860207 #FOAvip English Wikipedia <ref>{{Cite pmid|28860207}}</ref> PAF1 Regulation of Promoter-Proximal Pause Release via Enhancer Activation #MMPMID28860207 Chen FX; Xie P; Collings CK; Cao K; Aoi Y; Marshall SA; Rendleman EJ; Ugarenko M; Ozark PA; Zhang A; Shiekhattar R; Smith ER; Zhang MQ; Shilatifard A Science 2017[Sep]; 357 (6357): 1294-8 PMID28860207show ga Gene expression in metazoans is regulated by RNA Polymerase II (Pol II) promoter-proximal pausing and its release. Previously, we identified that Pol II-associated factor 1 (PAF1) modulates the release of paused Pol II into productive elongation. Here, we find that PAF1 occupies transcriptional enhancers and restrains hyperactivation of a subset of these enhancers. Enhancer activation as the result of PAF1 loss releases Pol II from paused promoters of nearby PAF1 target genes. Knockout of PAF1-regulated enhancers attenuates the release of paused Pol II on PAF1 target genes without major interference in the establishment of pausing at their cognate promoters. Thus, a subset of enhancers can primarily modulate gene expression by controlling the release of paused Pol II in a PAF1-dependent manner. äPAF1 Regulation of Promoter-Proximal Pause Release via Enhancer Activa(epmc).pdf DeepDyve Pubget Overpricing