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10.1073/pnas.1717730115 http://scihub22266oqcxt.onion/10.1073/pnas.1717730115 C6055145!6055145!29967174     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29967174&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (29): E6697-706 Nephropedia Template TP {{tp|p=29967174|t=2018. Chromatin organization by an interplay of loop extrusion and compartmental segregation |pdf=|usr=}}{{29967174}} gab.com Text Chromatin organization by an interplay of loop extrusion and compartmental segregation JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29967174 #FOAvip Human DNA is 2 m long and is folded into a 10-?m-sized cellular nucleus. Experiments have revealed two major features of genome organization: Segregation of alternating active and inactive regions into compartments, and formation of compacted local domains. These were hypothesized to be formed by different mechanisms: Compartments can be formed by microphase separation and domains by active, motor-driven, loop extrusion. Here, we integrate these mechanisms into a polymer model and show that their interplay coherently explains diverse experimental data for wild-type and mutant cells. Our results provide a framework for the interpretation of chromosome organization in cellular phenotypes and highlight that chromatin is a complex, active matter shaped by an interplay of phase segregation and loop extrusion. Twit Text FOAVip Chromatin organization by an interplay of loop extrusion and compartmental segregation ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29967174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29967174 #FOAvip English Wikipedia <ref>{{Cite pmid|29967174}}</ref> Chromatin organization by an interplay of loop extrusion and compartmental segregation #MMPMID29967174 Nuebler J; Fudenberg G; Imakaev M; Abdennur N; Mirny LA Proc Natl Acad Sci U S A 2018[Jul]; 115 (29): E6697-706 PMID29967174show ga Human DNA is 2 m long and is folded into a 10-?m-sized cellular nucleus. Experiments have revealed two major features of genome organization: Segregation of alternating active and inactive regions into compartments, and formation of compacted local domains. These were hypothesized to be formed by different mechanisms: Compartments can be formed by microphase separation and domains by active, motor-driven, loop extrusion. Here, we integrate these mechanisms into a polymer model and show that their interplay coherently explains diverse experimental data for wild-type and mutant cells. Our results provide a framework for the interpretation of chromosome organization in cellular phenotypes and highlight that chromatin is a complex, active matter shaped by an interplay of phase segregation and loop extrusion. äChromatin organization by an interplay of loop extrusion and compartme(epmc).pdf DeepDyve Pubget Overpricing