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Depressiveness and Neuroticism in Bartonella Seropositive and Seronegative
Subjects-Preregistered Case-Controls Study
#MMPMID30061846
Flegr J
; Preiss M
; Balátová P
Front Psychiatry
2018[]; 9
(?): 314
PMID30061846
show ga
Several recent studies have demonstrated the association of cat-related injuries
with major depression and with depressiveness in the general population. It was
suggested that cat-scratch disease, the infection with the bacterium Bartonella
henselae, can be responsible for the observed association. However, no direct
evidence for the role of the Bartonella infection in this association has been
published until now. In this preregistered case-controls study performed on 250
healthy subjects tested earlier for the presence of anti-Toxoplasma IgG
antibodies, we searched for the positive association between presence of
anamnestic anti-Bartonella IgG antibodies and depressiveness measured with Beck
II inventory, depression subscale of neuroticism measured with N-70
questionnaire, and self-reported health problems. We found that that Bartonella
seropositivity was positively correlated with Beck depression only in
Toxoplasma-seronegative men and negatively correlated with health in
Toxoplasma-seronegative women. Bartonella seropositivity expressed protective
effects against Toxoplasma seropositivity-associated increased neuroticism in men
while Toxoplasma-seropositivity expressed protective effects against Bartonella
seropositivity-associated health problems in women. A comparison of the patterns
of association of mental and physical health problems with Bartonella
seropositivity and with reported cat-related injury suggests that different
factor, possibly infection with different pathogen transmitted by cat
related-injuries than the B. henselae, is responsible for the observed
association of cat related-injuries with depressiveness and major depression. The
existence of complex interactions between Bartonella seropositivity, Toxoplasma
seropositivity, and sex also suggest that the effect of symbionts on the host's
phenotype must by always studied in the context of other infections, and
separately for men and women.
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