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10.3389/fendo.2018.00387 http://scihub22266oqcxt.onion/10.3389/fendo.2018.00387 C6054964!6054964!30061863     free     free     free       Front+Endocrinol+(Lausanne) 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=30061863|t=2018. The Origin and Understanding of the Incretin Concept |pdf=|usr=}}{{30061863}} gab.com Text The Origin and Understanding of the Incretin Concept JO: Front Endocrinol (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=30061863 #FOAvip Gastrointestinal hormones that stimulate insulin secretion at physiological concentrations are incretins. This concept has recently attracted considerable attention in the wake of drugs developed from the gut hormone GLP-1 (glucagon-like peptide-1) for diabetes therapy. But the renewed enthusiasm has also restricted the concept to just two hormones, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide). The purpose of the present overview is two-fold: First to tell that the incretin concept is far from new. It has a more than a century long history full of ups and downs. Second, that the incretin concept may now have become too narrow. Thus, it is likely that incretin comprises additional gastrointestinal hormones, which interact with GIP and GLP-1 during normal meals containing protein, fat and complex carbohydrates (and not just pure glucose). Such broader incretin concept may stimulate development of novel gut hormone-derived drugs. Twit Text FOAVip The Origin and Understanding of the Incretin Concept ????Front Endocrinol (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=30061863 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30061863 #FOAvip English Wikipedia <ref>{{Cite pmid|30061863}}</ref> The Origin and Understanding of the Incretin Concept #MMPMID30061863 Rehfeld JF Front Endocrinol (Lausanne) 2018[]; 9 (ä): ä PMID30061863show ga Gastrointestinal hormones that stimulate insulin secretion at physiological concentrations are incretins. This concept has recently attracted considerable attention in the wake of drugs developed from the gut hormone GLP-1 (glucagon-like peptide-1) for diabetes therapy. But the renewed enthusiasm has also restricted the concept to just two hormones, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide). The purpose of the present overview is two-fold: First to tell that the incretin concept is far from new. It has a more than a century long history full of ups and downs. Second, that the incretin concept may now have become too narrow. Thus, it is likely that incretin comprises additional gastrointestinal hormones, which interact with GIP and GLP-1 during normal meals containing protein, fat and complex carbohydrates (and not just pure glucose). Such broader incretin concept may stimulate development of novel gut hormone-derived drugs. äThe Origin and Understanding of the Incretin Concept (epmc).pdf DeepDyve Pubget Overpricing