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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Pharmacol
2018 ; 9
(ä): 762
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Salvia Miltiorrhiza Ameliorates Liver Fibrosis by Activating Hepatic Natural
Killer Cells in Vivo and in Vitro
#MMPMID30061833
Peng Y
; Yang T
; Huang K
; Shen L
; Tao Y
; Liu C
Front Pharmacol
2018[]; 9
(ä): 762
PMID30061833
show ga
Natural killer (NK) cells are known for their ability to kill activated hepatic
stellate cells (HSCs), which has been confirmed both in patients and animal
models. But the killing function is depressed in period of advanced liver injury.
Salvia Miltiorrhiza (SM), a Chinese herbal medicine for invigorating blood
circulation and eliminating stasis, is widely used to treat liver fibrosis in
clinic. Nevertheless, the immunological mechanism remains unclearly. Here, we put
forward the hypothesis that the anti-fibrotic effect of SM is concerned with
boosting the activation of hepatic NK cells. Liver fibrosis was induced with
carbon tetrachloride (CCl(4)) and effects of SM on NK cells and HSC (JS-1 cell
line, HSC) were investigated in vivo and in vitro. Hepatic NK cells were isolated
from C57BL/6 mice, and pre-incubated with SM before they were co-cultured with
HSCs. We found that SM increased frequency of NK cells, enhanced activities of
NKG2D and Nkp46 on NK cells and inhibited activation of HSCs in vivo and in
vitro. SM could promote the activities of NK cells by increasing the expressions
of NKG2D and IFN-? before or after co-cultured with HSCs in vitro. Besides, SM
could partially antagonize ASGM-1-induced NK cell depletion and enhance the cell
activities to inhibit HSCs activation in vitro. Therefore, our work provided a
new insight into the anti-fibrotic mechanism that SM could enhance the activities
of NK cell to reduce liver fibrosis in vivo and in vitro.
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