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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 World+J+Gastroenterol
2018 ; 24
(27
): 3013-3020
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Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment
of hepatic steatosis and fibrosis in children
#MMPMID30038468
Shin HJ
; Yoon H
; Kim MJ
; Han SJ
; Koh H
; Kim S
; Lee MJ
World J Gastroenterol
2018[Jul]; 24
(27
): 3013-3020
PMID30038468
show ga
AIM: To evaluate the correlation between intravoxel incoherent motion (IVIM)
diffusion-weighted imaging (DWI) parameters and the degree of hepatic steatosis
and fibrosis in children. METHODS: This retrospective study was approved by the
institutional review board. The children (? 18 years) who underwent liver IVIM
DWI with 8 b-values under the suspicion of hepatic steatosis or fibrosis from
February 2013 to November 2016 were included. Subjects were divided into normal,
fatty liver (FAT), and fibrotic liver (FIB) groups. The slow diffusion
coefficient (D), fast diffusion coefficient (D*), perfusion fraction (f), and
apparent diffusion coefficient (ADC) were measured. MR proton density fat
fraction (PDFF), MR elastography (MRE), and IVIM values were compared. RESULTS: A
total of 123 children (median age of 12 years old, range: 6-18 years) were
included, with 8 in the normal group, 93 in the FAT group, and 22 in the FIB
group. The D* values were lower in the FIB group compared with those of the
normal (P = 0.015) and FAT (P = 0.003) groups. The f values were lower in the FIB
group compared with the FAT group (P = 0.001). In multivariate analyses, PDFF
value was positively correlated with f value (? = 3.194, P < 0.001), and MRE
value was negatively correlated with D* value (? = -7.031, P = 0.032). The D and
ADC values were not influenced by PDFF or MRE value. CONCLUSION: In liver IVIM
DWI with multiple b-values in children, there was a positive correlation between
hepatic fat and blood volume, and a negative correlation between hepatic
stiffness and endovascular blood flow velocity, while diffusion-related
parameters were not affected.
|Adolescent
[MESH]
|Child
[MESH]
|Diffusion Magnetic Resonance Imaging/*methods
[MESH]