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10.3389/fimmu.2018.01655 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.01655 C6054939!6054939 !30061902     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30061902 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Front+Immunol 2018 ; 9 (?): 1655 Nephropedia Template TP {{tp|p=30061902 |t=2018. Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade |pdf=|usr=}}{{30061902 }} gab.com Text Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=30061902 #FOAvip Tissue-resident memory T (T(RM)) cells are a distinct subset of memory T cells that reside in non-lymphoid tissues for prolonged periods of time without significant recirculation providing continued immune surveillance at these sites. Recent studies suggest that T(RM) cells are also enriched within tumor tissue. Expression of inhibitory immune checkpoints (ICPs) is particularly enriched on this subset of tumor-infiltrating T cells, suggesting that they are major targets for newer therapies targeting ICPs such as the programmed death-1 pathway. Recent studies suggest that tissue restriction of these cells without recirculation may also lead to heterogeneity of T(RM) cells within individual metastatic lesions, ultimately leading to inter-lesional diversity. Thus, individual metastatic lesions may contain genomically distinct immune microenvironments that impact both evolution of tumors as well as the mechanisms underlying response and resistance to immune therapies. Understanding the biology of T(RM) cells infiltrating tumors will be essential to improving immune-based approaches in diverse settings. Twit Text FOAVip Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=30061902 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30061902 #FOAvip English Wikipedia <ref>{{Cite pmid|30061902 }}</ref> Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade #MMPMID30061902 Dhodapkar KM Front Immunol 2018[]; 9 (?): 1655 PMID30061902 show ga Tissue-resident memory T (T(RM)) cells are a distinct subset of memory T cells that reside in non-lymphoid tissues for prolonged periods of time without significant recirculation providing continued immune surveillance at these sites. Recent studies suggest that T(RM) cells are also enriched within tumor tissue. Expression of inhibitory immune checkpoints (ICPs) is particularly enriched on this subset of tumor-infiltrating T cells, suggesting that they are major targets for newer therapies targeting ICPs such as the programmed death-1 pathway. Recent studies suggest that tissue restriction of these cells without recirculation may also lead to heterogeneity of T(RM) cells within individual metastatic lesions, ultimately leading to inter-lesional diversity. Thus, individual metastatic lesions may contain genomically distinct immune microenvironments that impact both evolution of tumors as well as the mechanisms underlying response and resistance to immune therapies. Understanding the biology of T(RM) cells infiltrating tumors will be essential to improving immune-based approaches in diverse settings. ?Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Respon(epmc).pdf DeepDyve Pubget Overpricing