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10.1038/s41467-018-05336-9 http://scihub22266oqcxt.onion/10.1038/s41467-018-05336-9 C6054678!6054678 !30030441     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30030441 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2018 ; 9 (1 ): 2872 Nephropedia Template TP {{tp|p=30030441 |t=2018. Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism |pdf=|usr=}}{{30030441 }} gab.com Text Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30030441 #FOAvip Antibiotic-induced microbiome depletion (AIMD) has been used frequently to study the role of the gut microbiome in pathological conditions. However, unlike germ-free mice, the effects of AIMD on host metabolism remain incompletely understood. Here we show the effects of AIMD to elucidate its effects on gut homeostasis, luminal signaling, and metabolism. We demonstrate that AIMD, which decreases luminal Firmicutes and Bacteroidetes species, decreases baseline serum glucose levels, reduces glucose surge in a tolerance test, and improves insulin sensitivity without altering adiposity. These changes occur in the setting of decreased luminal short-chain fatty acids (SCFAs), especially butyrate, and the secondary bile acid pool, which affects whole-body bile acid metabolism. In mice, AIMD alters cecal gene expression and gut glucagon-like peptide 1 signaling. Extensive tissue remodeling and decreased availability of SCFAs shift colonocyte metabolism toward glucose utilization. We suggest that AIMD alters glucose homeostasis by potentially shifting colonocyte energy utilization from SCFAs to glucose. Twit Text FOAVip Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30030441 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30030441 #FOAvip English Wikipedia <ref>{{Cite pmid|30030441 }}</ref> Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism #MMPMID30030441 Zarrinpar A ; Chaix A ; Xu ZZ ; Chang MW ; Marotz CA ; Saghatelian A ; Knight R ; Panda S Nat Commun 2018[Jul]; 9 (1 ): 2872 PMID30030441 show ga Antibiotic-induced microbiome depletion (AIMD) has been used frequently to study the role of the gut microbiome in pathological conditions. However, unlike germ-free mice, the effects of AIMD on host metabolism remain incompletely understood. Here we show the effects of AIMD to elucidate its effects on gut homeostasis, luminal signaling, and metabolism. We demonstrate that AIMD, which decreases luminal Firmicutes and Bacteroidetes species, decreases baseline serum glucose levels, reduces glucose surge in a tolerance test, and improves insulin sensitivity without altering adiposity. These changes occur in the setting of decreased luminal short-chain fatty acids (SCFAs), especially butyrate, and the secondary bile acid pool, which affects whole-body bile acid metabolism. In mice, AIMD alters cecal gene expression and gut glucagon-like peptide 1 signaling. Extensive tissue remodeling and decreased availability of SCFAs shift colonocyte metabolism toward glucose utilization. We suggest that AIMD alters glucose homeostasis by potentially shifting colonocyte energy utilization from SCFAs to glucose. |Amphotericin B/administration & dosage [MESH] |Ampicillin/administration & dosage [MESH] |Animals [MESH] |Anti-Bacterial Agents/*pharmacology [MESH] |Bile Acids and Salts/chemistry [MESH] |Blood Glucose/metabolism [MESH] |Body Composition [MESH] |Body Weight [MESH] |Cecum/metabolism [MESH] |Colon/drug effects/metabolism/*microbiology [MESH] |Fatty Acids, Volatile/chemistry [MESH] |Gastrointestinal Microbiome/*drug effects [MESH] |Gene Expression Regulation [MESH] |Glucose/metabolism [MESH] |Homeostasis [MESH] |Insulin Resistance [MESH] |Insulin/metabolism [MESH] |Male [MESH] |Metronidazole/administration & dosage [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Neomycin/administration & dosage [MESH] |Obesity/drug therapy/metabolism/*microbiology [MESH] |RNA, Ribosomal, 16S/metabolism [MESH]Antibiotic-induced microbiome depletion alters metabolic homeostasis b(epmc).pdf DeepDyve Pubget Overpricing