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10.1038/s41467-018-05167-8 http://scihub22266oqcxt.onion/10.1038/s41467-018-05167-8 C6054648!6054648!30030423     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=30030423|t=2018. TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity |pdf=|usr=}}{{30030423}} gab.com Text TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30030423 #FOAvip Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that recipient CD4+ T cell responses are actively regulated through direct allorecognition of donor-derived Mregs. Here we show that human Mregs convert allogeneic CD4+ T cells to IL-10-producing, TIGIT+ FoxP3+-induced regulatory T cells that non-specifically suppress bystander T cells and inhibit dendritic cell maturation. Differentiation of Mreg-induced Tregs relies on multiple non-redundant mechanisms that are not exclusive to interaction of Mregs and T cells, including signals mediated by indoleamine 2,3-dioxygenase, TGF-?, retinoic acid, Notch and progestagen-associated endometrial protein. Preoperative administration of donor-derived Mregs to living-donor kidney transplant recipients results in an acute increase in circulating TIGIT+ Tregs. These results suggest a feed-forward mechanism by which Mreg treatment promotes allograft acceptance through rapid induction of direct-pathway Tregs. Twit Text FOAVip TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30030423 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30030423 #FOAvip English Wikipedia <ref>{{Cite pmid|30030423}}</ref> TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity #MMPMID30030423 Riquelme P; Haarer J; Kammler A; Walter L; Tomiuk S; Ahrens N; Wege AK; Goecze I; Zecher D; Banas B; Spang R; Fändrich F; Lutz MB; Sawitzki B; Schlitt HJ; Ochando J; Geissler EK; Hutchinson JA Nat Commun 2018[]; 9 (ä): ä PMID30030423show ga Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that recipient CD4+ T cell responses are actively regulated through direct allorecognition of donor-derived Mregs. Here we show that human Mregs convert allogeneic CD4+ T cells to IL-10-producing, TIGIT+ FoxP3+-induced regulatory T cells that non-specifically suppress bystander T cells and inhibit dendritic cell maturation. Differentiation of Mreg-induced Tregs relies on multiple non-redundant mechanisms that are not exclusive to interaction of Mregs and T cells, including signals mediated by indoleamine 2,3-dioxygenase, TGF-?, retinoic acid, Notch and progestagen-associated endometrial protein. Preoperative administration of donor-derived Mregs to living-donor kidney transplant recipients results in an acute increase in circulating TIGIT+ Tregs. These results suggest a feed-forward mechanism by which Mreg treatment promotes allograft acceptance through rapid induction of direct-pathway Tregs. äTIGIT+ iTregs elicited by human regulatory macrophages control T cell (epmc).pdf DeepDyve Pubget Overpricing