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10.1038/s41598-018-28634-0 http://scihub22266oqcxt.onion/10.1038/s41598-018-28634-0 C6054610!6054610!30030504     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=30030504|t=2018. Neuroepithelial control of mucosal inflammation in acute cystitis |pdf=|usr=}}{{30030504}} gab.com Text Neuroepithelial control of mucosal inflammation in acute cystitis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30030504 #FOAvip The nervous system is engaged by infection, indirectly through inflammatory cascades or directly, by bacterial attack on nerve cells. Here we identify a neuro-epithelial activation loop that participates in the control of mucosal inflammation and pain in acute cystitis. We show that infection activates Neurokinin-1 receptor (NK1R) and Substance P (SP) expression in nerve cells and bladder epithelial cells in vitro and in vivo in the urinary bladder mucosa. Specific innate immune response genes regulated this mucosal response, and single gene deletions resulted either in protection (Tlr4?/? and Il1b?/? mice) or in accentuated bladder pathology (Asc?/? and Nlrp3?/? mice), compared to controls. NK1R/SP expression was lower in Tlr4?/? and Il1b?/? mice than in C56BL/6WT controls but in Asc?/? and Nlrp3?/? mice, NK1R over-activation accompanied the exaggerated disease phenotype, due, in part to transcriptional de-repression of Tacr1. Pharmacologic NK1R inhibitors attenuated acute cystitis in susceptible mice, supporting a role in disease pathogenesis. Clinical relevance was suggested by elevated urine SP levels in patients with acute cystitis, compared to patients with asymptomatic bacteriuria identifying NK1R/SP as potential therapeutic targets. We propose that NK1R and SP influence the severity of acute cystitis through a neuro-epithelial activation loop that controls pain and mucosal inflammation. Twit Text FOAVip Neuroepithelial control of mucosal inflammation in acute cystitis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30030504 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30030504 #FOAvip English Wikipedia <ref>{{Cite pmid|30030504}}</ref> Neuroepithelial control of mucosal inflammation in acute cystitis #MMPMID30030504 Butler DSC; Ambite I; Nagy K; Cafaro C; Ahmed A; Nadeem A; Filenko N; Tran TH; Andersson KE; Wullt B; Puthia M; Svanborg C Sci Rep 2018[]; 8 (ä): ä PMID30030504show ga The nervous system is engaged by infection, indirectly through inflammatory cascades or directly, by bacterial attack on nerve cells. Here we identify a neuro-epithelial activation loop that participates in the control of mucosal inflammation and pain in acute cystitis. We show that infection activates Neurokinin-1 receptor (NK1R) and Substance P (SP) expression in nerve cells and bladder epithelial cells in vitro and in vivo in the urinary bladder mucosa. Specific innate immune response genes regulated this mucosal response, and single gene deletions resulted either in protection (Tlr4?/? and Il1b?/? mice) or in accentuated bladder pathology (Asc?/? and Nlrp3?/? mice), compared to controls. NK1R/SP expression was lower in Tlr4?/? and Il1b?/? mice than in C56BL/6WT controls but in Asc?/? and Nlrp3?/? mice, NK1R over-activation accompanied the exaggerated disease phenotype, due, in part to transcriptional de-repression of Tacr1. Pharmacologic NK1R inhibitors attenuated acute cystitis in susceptible mice, supporting a role in disease pathogenesis. Clinical relevance was suggested by elevated urine SP levels in patients with acute cystitis, compared to patients with asymptomatic bacteriuria identifying NK1R/SP as potential therapeutic targets. We propose that NK1R and SP influence the severity of acute cystitis through a neuro-epithelial activation loop that controls pain and mucosal inflammation. äNeuroepithelial control of mucosal inflammation in acute cystitis (epmc).pdf DeepDyve Pubget Overpricing