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10.1080/14756366.2017.1419219 http://scihub22266oqcxt.onion/10.1080/14756366.2017.1419219 C6054517!6054517!29303372     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Enzyme+Inhib+Med+Chem 2018 ; 33 (1): 324-33 Nephropedia Template TP {{tp|p=29303372|t=2018. Design and synthesis of novel oridonin analogues as potent anticancer agents |pdf=|usr=}}{{29303372}} gab.com Text Design and synthesis of novel oridonin analogues as potent anticancer agents JO: J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=29303372 #FOAvip To identify anticancer agents with higher potency and lower toxicity, a series of oridonin derivatives with substituted benzene moieties at the C17 position were designed, synthesised, and evaluated for their antiproliferative properties. Most of the derivatives exhibited antiproliferative effects against AGS, MGC803, Bel7402, HCT116, A549, and HeLa cells. Compound 2p (IC50?=?1.05?µM) exhibited the most potent antiproliferative activity against HCT116 cells; it was more potent than oridonin (IC50?=?6.84?µM) and 5-fluorouracil (5-FU) (IC50?=?24.80?µM). The IC50 value of 2p in L02 cells was 6.5-fold higher than that in HCT116 cells. Overall, it exhibited better selective antiproliferative activity and specificity than oridonin and 5-FU. Furthermore, compound 2p arrested HCT116 cells at the G2 phase of the cell cycle and increased the percentage of apoptotic cells to a greater extent than oridonin. Twit Text FOAVip Design and synthesis of novel oridonin analogues as potent anticancer agents ????J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=29303372 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29303372 #FOAvip English Wikipedia <ref>{{Cite pmid|29303372}}</ref> Design and synthesis of novel oridonin analogues as potent anticancer agents #MMPMID29303372 Shen QK; Chen ZA; Zhang HJ; Li JL; Liu CF; Gong GH; Quan ZS J Enzyme Inhib Med Chem 2018[]; 33 (1): 324-33 PMID29303372show ga To identify anticancer agents with higher potency and lower toxicity, a series of oridonin derivatives with substituted benzene moieties at the C17 position were designed, synthesised, and evaluated for their antiproliferative properties. Most of the derivatives exhibited antiproliferative effects against AGS, MGC803, Bel7402, HCT116, A549, and HeLa cells. Compound 2p (IC50?=?1.05?µM) exhibited the most potent antiproliferative activity against HCT116 cells; it was more potent than oridonin (IC50?=?6.84?µM) and 5-fluorouracil (5-FU) (IC50?=?24.80?µM). The IC50 value of 2p in L02 cells was 6.5-fold higher than that in HCT116 cells. Overall, it exhibited better selective antiproliferative activity and specificity than oridonin and 5-FU. Furthermore, compound 2p arrested HCT116 cells at the G2 phase of the cell cycle and increased the percentage of apoptotic cells to a greater extent than oridonin. äDesign and synthesis of novel oridonin analogues as potent anticancer (epmc).pdf DeepDyve Pubget Overpricing