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10.1016/j.prostaglandins.2016.11.002 http://scihub22266oqcxt.onion/10.1016/j.prostaglandins.2016.11.002 C6053630!6053630!27871801     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Prostaglandins+Other+Lipid+Mediat 2016 ; 127 (ä): 1-8 Nephropedia Template TP {{tp|p=27871801|t=2016. Lipid Profiling of Polarized Human Monocyte-derived Macrophages |pdf=|usr=}}{{27871801}} gab.com Text Lipid Profiling of Polarized Human Monocyte-derived Macrophages JO: Prostaglandins Other Lipid Mediat http://www.kidney.de/pget.php?&tw=1&pmid=27871801 #FOAvip The highly orchestrated transcriptional and metabolic reprogramming during activation drastically transforms the main functions and physiology of human macrophages across the polarization spectrum. Lipids, for example, can modify protein function by acting remotely as signaling molecules but also locally by altering the physical properties of cellular membranes. These changes play key roles in the functions of highly plastic immune cells due to their involvement in inflammation, immune responses, phagocytosis and wound healing processes. We report an analysis of major membrane lipids of distinct phenotypes of resting (M0), classically activated (M1), alternatively activated (M2a) and deactivated (M2c) human monocyte derived macrophages from different donors. Samples were subjected to supercritical fluid chromatography-ion mobility-mass spectrometry analysis, which allowed separations based on lipid class, facilitating the profiling of their fatty acid composition. Different levels of arachidonic acid mobilization as well as other fatty acid changes were observed for different lipid classes in the distinct polarization phenotypes, suggesting the activation of highly orchestrated and specific enzymatic processes in the biosynthesis of lipid signaling molecules and cell membrane remodeling. Thromboxane A2 production appeared to be a specific marker of M1 polarization. These alterations to the global composition of lipid bi-layer membranes in the cell provide a potential methodology for the definition and determination of cellular and tissue activation states. Twit Text FOAVip Lipid Profiling of Polarized Human Monocyte-derived Macrophages ????Prostaglandins Other Lipid Mediat http://www.kidney.de/pget.php?&tw=1&pmid=27871801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27871801 #FOAvip English Wikipedia <ref>{{Cite pmid|27871801}}</ref> Lipid Profiling of Polarized Human Monocyte-derived Macrophages #MMPMID27871801 Montenegro-Burke JR; Sutton JA; Rogers LM; Milne GL; McLean JA; Aronoff DM Prostaglandins Other Lipid Mediat 2016[Dec]; 127 (ä): 1-8 PMID27871801show ga The highly orchestrated transcriptional and metabolic reprogramming during activation drastically transforms the main functions and physiology of human macrophages across the polarization spectrum. Lipids, for example, can modify protein function by acting remotely as signaling molecules but also locally by altering the physical properties of cellular membranes. These changes play key roles in the functions of highly plastic immune cells due to their involvement in inflammation, immune responses, phagocytosis and wound healing processes. We report an analysis of major membrane lipids of distinct phenotypes of resting (M0), classically activated (M1), alternatively activated (M2a) and deactivated (M2c) human monocyte derived macrophages from different donors. Samples were subjected to supercritical fluid chromatography-ion mobility-mass spectrometry analysis, which allowed separations based on lipid class, facilitating the profiling of their fatty acid composition. Different levels of arachidonic acid mobilization as well as other fatty acid changes were observed for different lipid classes in the distinct polarization phenotypes, suggesting the activation of highly orchestrated and specific enzymatic processes in the biosynthesis of lipid signaling molecules and cell membrane remodeling. Thromboxane A2 production appeared to be a specific marker of M1 polarization. These alterations to the global composition of lipid bi-layer membranes in the cell provide a potential methodology for the definition and determination of cellular and tissue activation states. äLipid Profiling of Polarized Human Monocyte-derived Macrophages (epmc).pdf DeepDyve Pubget Overpricing