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2018 ; 8
(1
): 10939
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gab.com Text
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English Wikipedia
Predictors of Early Onset Multiple Organ Dysfunction in Major Burn Patients with
Ventilator Support: Experience from A Mass Casualty Explosion
#MMPMID30026512
Feng JY
; Chien JY
; Kao KC
; Tsai CL
; Hung FM
; Lin FM
; Hu HC
; Huang KL
; Yu CJ
; Yang KY
Sci Rep
2018[Jul]; 8
(1
): 10939
PMID30026512
show ga
Organ dysfunction is common in patients with major burns and associated with poor
outcomes. The risk factors for early onset multiple organ dysfunction syndrome
(MODS) in major burn patients with invasive ventilator support has rarely been
evaluated before. In this study, major burn patients with invasive ventilator
support from 499 victims suffered in a mass casualty color dust explosion were
retrospectively enrolled. The development of early MODS that occurred within 5
days after burn injury was determined and the risk factors associated with early
MODS were analyzed. A total of 88 patients from five medical centers were
included. Their mean total body surface area (TBSA) was 60.9?±?15.8%, and 45
(51.1%) patients had early MODS. Hematologic failure was the most common organ
failure (68.6%), followed by respiratory failure (48.9%). Independent clinical
factors associated with early MODS included TBSA ?55% (OR: 3.83; 95% CI:
1.29-11.37) and serum albumin level <2.1?g/dL upon admission (OR: 3.43; 95% CI:
1.01-11.57). Patients with early MODS had prolonged ventilator dependence and
longer ICU admission than those without early MODS. Our results showed that early
MODS in major burn patients with invasive ventilator support is very common and
can be predicted early on admission.