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10.1038/s41598-018-29101-6 http://scihub22266oqcxt.onion/10.1038/s41598-018-29101-6 C6053448!6053448!30026594     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=30026594|t=2018. Small molecule activator of Nm23/NDPK as an inhibitor of metastasis |pdf=|usr=}}{{30026594}} gab.com Text Small molecule activator of Nm23/NDPK as an inhibitor of metastasis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30026594 #FOAvip Nm23-H1/NDPK-A is a tumor metastasis suppressor having NDP kinase (NDPK) activity. Nm23-H1 is positively associated with prolonged disease-free survival and good prognosis of cancer patients. Approaches to increasing the cellular levels of Nm23-H1 therefore have significance in the therapy of metastatic cancers. We found a small molecule, (±)-trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, that activates Nm23, hereafter called NMac1. NMac1 directly binds to Nm23-H1 and increases its NDPK activity. Employing various NMac1 derivatives and hydrogen/deuterium mass spectrometry (HDX-MS), we identified the pharmacophore and mode of action of NMac1. We found that NMac1 binds to the C-terminal of Nm23-H1 and induces the NDPK activation through its allosteric conformational changes. NMac1-treated MDA-MB-231 breast cancer cells showed dramatic changes in morphology and actin-cytoskeletal organization following inhibition of Rac1 activation. NMac1 also suppressed invasion and migration in vitro, and metastasis in vivo, in a breast cancer mouse model. NMac1 as an activator of NDPK has potential as an anti-metastatic agent. Twit Text FOAVip Small molecule activator of Nm23/NDPK as an inhibitor of metastasis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30026594 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30026594 #FOAvip English Wikipedia <ref>{{Cite pmid|30026594}}</ref> Small molecule activator of Nm23/NDPK as an inhibitor of metastasis #MMPMID30026594 Lee JJ; Kim HS; Lee JS; Park J; Shin SC; Song S; Lee E; Choi JE; Suh JW; Lee H; Kim EE; Seo EK; Shin DH; Lee HY; Lee HY; Lee KJ Sci Rep 2018[]; 8 (ä): ä PMID30026594show ga Nm23-H1/NDPK-A is a tumor metastasis suppressor having NDP kinase (NDPK) activity. Nm23-H1 is positively associated with prolonged disease-free survival and good prognosis of cancer patients. Approaches to increasing the cellular levels of Nm23-H1 therefore have significance in the therapy of metastatic cancers. We found a small molecule, (±)-trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, that activates Nm23, hereafter called NMac1. NMac1 directly binds to Nm23-H1 and increases its NDPK activity. Employing various NMac1 derivatives and hydrogen/deuterium mass spectrometry (HDX-MS), we identified the pharmacophore and mode of action of NMac1. We found that NMac1 binds to the C-terminal of Nm23-H1 and induces the NDPK activation through its allosteric conformational changes. NMac1-treated MDA-MB-231 breast cancer cells showed dramatic changes in morphology and actin-cytoskeletal organization following inhibition of Rac1 activation. NMac1 also suppressed invasion and migration in vitro, and metastasis in vivo, in a breast cancer mouse model. NMac1 as an activator of NDPK has potential as an anti-metastatic agent. äSmall molecule activator of Nm23/NDPK as an inhibitor of metastasis (epmc).pdf DeepDyve Pubget Overpricing