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10.1038/s41598-018-28536-1 http://scihub22266oqcxt.onion/10.1038/s41598-018-28536-1 C6053398!6053398!30026484     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30026484&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=30026484|t=2018. FTY720 restores endothelial cell permeability induced by malaria sera |pdf=|usr=}}{{30026484}} gab.com Text FTY720 restores endothelial cell permeability induced by malaria sera JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30026484 #FOAvip Increased endothelial cell (EC) permeability in severe Plasmodium falciparum malaria contributes to major complications of severe malaria. This study explored EC permeability in malaria, and evaluated the potential use of FTY720 to restore EC permeability. ECs were incubated with sera from malaria patients (P. vivax, uncomplicated and complicated P. falciparum malaria). Cellular permeability was investigated using a fluorescein isothiocyanate (FITC)-dextran permeability assay. FTY720, an analogue of sphingosine-1-phosphate (S1P), was tested for its potential action in maintaining EC integrity. ECs incubated with sera from malaria patients with complicated P. falciparum showed higher fluorescein leakage compared with ECs incubated with sera from P. vivax (p?<?0.001) and uncomplicated P. falciparum (p?<?0.001). ECs pretreated with FTY720 before incubation with malaria sera had significantly decreased fluorescein leakage compared with no FTY720 treatment. In addition, FTY720 treatment significantly reduced fluorescein leakage for both uncomplicated (at 45?min) (p?=?0.015), and complicated P. falciparum malaria (15?min) (p?=?0.043). The permeability increase induced by complicated P. falciparum sera was significantly reversed and prevented by FTY720 in vitro. FTY720 may have clinical applications to protect against endothelial barrier dysfunction in severe P. falciparum malaria. Twit Text FOAVip FTY720 restores endothelial cell permeability induced by malaria sera ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30026484 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30026484 #FOAvip English Wikipedia <ref>{{Cite pmid|30026484}}</ref> FTY720 restores endothelial cell permeability induced by malaria sera #MMPMID30026484 Oggungwan K; Glaharn S; Ampawong S; Krudsood S; Viriyavejakul P Sci Rep 2018[]; 8 (ä): ä PMID30026484show ga Increased endothelial cell (EC) permeability in severe Plasmodium falciparum malaria contributes to major complications of severe malaria. This study explored EC permeability in malaria, and evaluated the potential use of FTY720 to restore EC permeability. ECs were incubated with sera from malaria patients (P. vivax, uncomplicated and complicated P. falciparum malaria). Cellular permeability was investigated using a fluorescein isothiocyanate (FITC)-dextran permeability assay. FTY720, an analogue of sphingosine-1-phosphate (S1P), was tested for its potential action in maintaining EC integrity. ECs incubated with sera from malaria patients with complicated P. falciparum showed higher fluorescein leakage compared with ECs incubated with sera from P. vivax (p? äFTY720 restores endothelial cell permeability induced by malaria sera (epmc).pdf DeepDyve Pubget Overpricing