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10.1038/s41467-018-05187-4 http://scihub22266oqcxt.onion/10.1038/s41467-018-05187-4 C6053369!6053369!30026585     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=30026585|t=2018. SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix |pdf=|usr=}}{{30026585}} gab.com Text SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30026585 #FOAvip SP7/Osterix (OSX) is a master regulatory transcription factor that activates a variety of genes during differentiation of osteoblasts. However, the influence of post-translational modifications on the regulation of its transactivation activity is largely unknown. Here, we report that sirtuins, which are NAD(+)-dependent deacylases, regulate lysine deacylation-mediated transactivation of OSX. Germline Sirt7 knockout mice develop severe osteopenia characterized by decreased bone formation and an increase of osteoclasts. Similarly, osteoblast-specific Sirt7 knockout mice showed attenuated bone formation. Interaction of SIRT7 with OSX leads to the activation of transactivation by OSX without altering its protein expression. Deacylation of lysine (K) 368 in the C-terminal region of OSX by SIRT7 promote its N-terminal transactivation activity. In addition, SIRT7-mediated deacylation of K368 also facilitates depropionylation of OSX by SIRT1, thereby increasing OSX transactivation activity. In conclusion, our findings suggest that SIRT7 has a critical role in bone formation by regulating acylation of OSX. Twit Text FOAVip SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30026585 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30026585 #FOAvip English Wikipedia <ref>{{Cite pmid|30026585}}</ref> SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix #MMPMID30026585 Fukuda M; Yoshizawa T; Karim MF; Sobuz SU; Korogi W; Kobayasi D; Okanishi H; Tasaki M; Ono K; Sawa T; Sato Y; Chirifu M; Masuda T; Nakamura T; Tanoue H; Nakashima K; Kobashigawa Y; Morioka H; Bober E; Ohtsuki S; Yamagata Y; Ando Y; Oike Y; Araki N; Takeda S; Mizuta H; Yamagata K Nat Commun 2018[]; 9 (ä): ä PMID30026585show ga SP7/Osterix (OSX) is a master regulatory transcription factor that activates a variety of genes during differentiation of osteoblasts. However, the influence of post-translational modifications on the regulation of its transactivation activity is largely unknown. Here, we report that sirtuins, which are NAD(+)-dependent deacylases, regulate lysine deacylation-mediated transactivation of OSX. Germline Sirt7 knockout mice develop severe osteopenia characterized by decreased bone formation and an increase of osteoclasts. Similarly, osteoblast-specific Sirt7 knockout mice showed attenuated bone formation. Interaction of SIRT7 with OSX leads to the activation of transactivation by OSX without altering its protein expression. Deacylation of lysine (K) 368 in the C-terminal region of OSX by SIRT7 promote its N-terminal transactivation activity. In addition, SIRT7-mediated deacylation of K368 also facilitates depropionylation of OSX by SIRT1, thereby increasing OSX transactivation activity. In conclusion, our findings suggest that SIRT7 has a critical role in bone formation by regulating acylation of OSX. äSIRT7 has a critical role in bone formation by regulating lysine acyla(epmc).pdf DeepDyve Pubget Overpricing