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10.1038/s41388-018-0226-z http://scihub22266oqcxt.onion/10.1038/s41388-018-0226-z C6053357!6053357 !29662192     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29662192 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncogene 2018 ; 37 (29 ): 3953-3966 Nephropedia Template TP {{tp|p=29662192 |t=2018. Capillary morphogenesis gene 2 maintains gastric cancer stem-like cell phenotype by activating a Wnt/?-catenin pathway |pdf=|usr=}}{{29662192 }} gab.com Text Capillary morphogenesis gene 2 maintains gastric cancer stem-like cell phenotype by activating a Wnt/ -catenin pathway JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=29662192 #FOAvip A growing body of evidence shows that the development and progression of gastric cancer (GC) is mainly associated to the presence of gastric cancer stem-like cells (GCSLCs). However, it is unclear how GCSLC population is maintained. This study aimed to explore the role of capillary morphogenesis gene 2 (CMG2) in GCSLC maintenance and the relevance to GC progression. We found that CMG2 was highly expressed in GC tissues and the expression levels were associated with the invasion depth and lymph node metastasis of GC, and inversely correlated with the survival of GC patients. Sorted CMG2(High) GC cells preferentially clustered in CD44(High) stem-like cell population, which expressed high levels of stemness-related genes with increased capabilities of self-renewal and tumorigenicity. Depletion of CMG2 gene resulted in reduction of GCSLC population with attenuated stemness and decrease of invasive and metastatic capabilities with subdued epithelial-mesenchymal transition phenotype in GC cells. Mechanistically, CMG2 interacted with LRP6 in GCSLCs to activate a Wnt/?-catenin pathway. Thus, our results demonstrate that CMG2 promotes GC progression by maintaining GCSLCs and can serve as a new prognostic indicator and a target for human GC therapy. Twit Text FOAVip Capillary morphogenesis gene 2 maintains gastric cancer stem-like cell phenotype by activating a Wnt/ -catenin pathway ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=29662192 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29662192 #FOAvip English Wikipedia <ref>{{Cite pmid|29662192 }}</ref> Capillary morphogenesis gene 2 maintains gastric cancer stem-like cell phenotype by activating a Wnt/?-catenin pathway #MMPMID29662192 Ji C ; Yang L ; Yi W ; Xiang D ; Wang Y ; Zhou Z ; Qian F ; Ren Y ; Cui W ; Zhang X ; Zhang P ; Wang JM ; Cui Y ; Bian X Oncogene 2018[Jul]; 37 (29 ): 3953-3966 PMID29662192 show ga A growing body of evidence shows that the development and progression of gastric cancer (GC) is mainly associated to the presence of gastric cancer stem-like cells (GCSLCs). However, it is unclear how GCSLC population is maintained. This study aimed to explore the role of capillary morphogenesis gene 2 (CMG2) in GCSLC maintenance and the relevance to GC progression. We found that CMG2 was highly expressed in GC tissues and the expression levels were associated with the invasion depth and lymph node metastasis of GC, and inversely correlated with the survival of GC patients. Sorted CMG2(High) GC cells preferentially clustered in CD44(High) stem-like cell population, which expressed high levels of stemness-related genes with increased capabilities of self-renewal and tumorigenicity. Depletion of CMG2 gene resulted in reduction of GCSLC population with attenuated stemness and decrease of invasive and metastatic capabilities with subdued epithelial-mesenchymal transition phenotype in GC cells. Mechanistically, CMG2 interacted with LRP6 in GCSLCs to activate a Wnt/?-catenin pathway. Thus, our results demonstrate that CMG2 promotes GC progression by maintaining GCSLCs and can serve as a new prognostic indicator and a target for human GC therapy. |Animals [MESH] |Cell Line, Tumor [MESH] |Disease Progression [MESH] |Epithelial-Mesenchymal Transition/physiology [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic/physiology [MESH] |Humans [MESH] |Low Density Lipoprotein Receptor-Related Protein-6/metabolism [MESH] |Lymphatic Metastasis/pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Nude [MESH] |Middle Aged [MESH] |Neoplastic Stem Cells/*metabolism [MESH] |Phenotype [MESH] |Prognosis [MESH] |Receptors, Peptide/*metabolism [MESH] |Stomach Neoplasms/*metabolism/pathology [MESH] |Wnt Signaling Pathway/*physiology [MESH] |Xenograft Model Antitumor Assays [MESH]Capillary morphogenesis gene 2 maintains gastric cancer stem-like cell(epmc).pdf DeepDyve Pubget Overpricing