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10.1038/nmicrobiol.2016.11 http://scihub22266oqcxt.onion/10.1038/nmicrobiol.2016.11 C6053355!6053355!27572442     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Microbiol 2016 ; 1 (ä): 16011 Nephropedia Template TP {{tp|p=27572442|t=2016. Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells |pdf=|usr=}}{{27572442}} gab.com Text Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells JO: Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=27572442 #FOAvip N6-methyladenosine (m6A) is the most prevalent internal modification of eukaryotic mRNA. Very little is known of the function of m6A in the immune system or its role in host?pathogen interactions. Here we investigated the topology, dynamics, and bidirectional influences of the viral?host RNA methylomes during HIV-1 infection of human CD4 T cells. We show that viral infection triggers a massive increase in m6A in both host and viral mRNAs. In HIV-1 mRNA, we identified 14 methylation peaks in coding and noncoding regions, splicing junctions, and splicing regulatory sequences. We also identified a set of 56 human gene transcripts that were uniquely methylated in HIV-1-infected T cells and were enriched for functions in viral gene expression. The functional relevance of m6A for viral replication was demonstrated by silencing of the m6A writer or the eraser enzymes, which decreased or increased HIV-1 replication, respectively. Furthermore, methylation of two conserved adenosines in the stem loop II region of HIV-1 Rev Response Element (RRE) RNA enhanced binding of HIV-1 Rev protein to the RRE in vivo and influenced nuclear export of RNA. Our results identify a new mechanism for the control of HIV-1 replication and its interaction with the host immune system. Twit Text FOAVip Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells ????Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=27572442 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27572442 #FOAvip English Wikipedia <ref>{{Cite pmid|27572442}}</ref> Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells #MMPMID27572442 Lichinchi G; Gao S; Saletore Y; Gonzalez GM; Bansal V; Wang Y; Mason C; Rana TM Nat Microbiol 2016[Feb]; 1 (ä): 16011 PMID27572442show ga N6-methyladenosine (m6A) is the most prevalent internal modification of eukaryotic mRNA. Very little is known of the function of m6A in the immune system or its role in host?pathogen interactions. Here we investigated the topology, dynamics, and bidirectional influences of the viral?host RNA methylomes during HIV-1 infection of human CD4 T cells. We show that viral infection triggers a massive increase in m6A in both host and viral mRNAs. In HIV-1 mRNA, we identified 14 methylation peaks in coding and noncoding regions, splicing junctions, and splicing regulatory sequences. We also identified a set of 56 human gene transcripts that were uniquely methylated in HIV-1-infected T cells and were enriched for functions in viral gene expression. The functional relevance of m6A for viral replication was demonstrated by silencing of the m6A writer or the eraser enzymes, which decreased or increased HIV-1 replication, respectively. Furthermore, methylation of two conserved adenosines in the stem loop II region of HIV-1 Rev Response Element (RRE) RNA enhanced binding of HIV-1 Rev protein to the RRE in vivo and influenced nuclear export of RNA. Our results identify a new mechanism for the control of HIV-1 replication and its interaction with the host immune system. äDynamics of the human and viral m6A RNA methylomes during HIV-1 infect(epmc).pdf DeepDyve Pubget Overpricing