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10.1038/sj.leu.2405019

http://scihub22266oqcxt.onion/10.1038/sj.leu.2405019
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C6053313!6053313!17989719
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suck abstract from ncbi


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pmid17989719      Leukemia 2008 ; 22 (2): 400-5
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  • Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell #MMPMID17989719
  • Montesinos-Rongen M; Brunn A; Bentink S; Basso K; Lim W; Klapper W; Schaller C; Reifenberger G; Rubenstein J; Wiestler O; Spang R; Dalla-Favera R; Siebert R; Deckert M
  • Leukemia 2008[Feb]; 22 (2): 400-5 PMID17989719show ga
  • To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B-cell lymphomas (dLbCLs) and (iii) to be in part assigned to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) subtype of DLBCL.
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