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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Leukemia
2008 ; 22
(2
): 400-5
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Gene expression profiling suggests primary central nervous system lymphomas to be
derived from a late germinal center B cell
#MMPMID17989719
Montesinos-Rongen M
; Brunn A
; Bentink S
; Basso K
; Lim WK
; Klapper W
; Schaller C
; Reifenberger G
; Rubenstein J
; Wiestler OD
; Spang R
; Dalla-Favera R
; Siebert R
; Deckert M
Leukemia
2008[Feb]; 22
(2
): 400-5
PMID17989719
show ga
To characterize the molecular origin of primary lymphomas of the central nervous
system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by
microarray-based gene expression profiling. Comparison of the transcriptional
profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated
PCNSL (i) to display gene expression patterns most closely related to late
germinal center B cells, (ii) to display a gene expression profile similar to
systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned
to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB)
subtype of DLBCL.
|*Gene Expression Profiling
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|B-Lymphocytes/*pathology
[MESH]
|Central Nervous System Neoplasms/*genetics/pathology
[MESH]
|Female
[MESH]
|Germinal Center/*pathology
[MESH]
|Humans
[MESH]
|Immunocompetence
[MESH]
|Lymphoma, Large B-Cell, Diffuse/genetics/pathology
[MESH]