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10.1038/sj.leu.2405019

http://scihub22266oqcxt.onion/10.1038/sj.leu.2405019
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C6053313!6053313 !17989719
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suck abstract from ncbi


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pmid17989719
      Leukemia 2008 ; 22 (2 ): 400-5
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  • Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell #MMPMID17989719
  • Montesinos-Rongen M ; Brunn A ; Bentink S ; Basso K ; Lim WK ; Klapper W ; Schaller C ; Reifenberger G ; Rubenstein J ; Wiestler OD ; Spang R ; Dalla-Favera R ; Siebert R ; Deckert M
  • Leukemia 2008[Feb]; 22 (2 ): 400-5 PMID17989719 show ga
  • To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) subtype of DLBCL.
  • |*Gene Expression Profiling [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |B-Lymphocytes/*pathology [MESH]
  • |Central Nervous System Neoplasms/*genetics/pathology [MESH]
  • |Female [MESH]
  • |Germinal Center/*pathology [MESH]
  • |Humans [MESH]
  • |Immunocompetence [MESH]
  • |Lymphoma, Large B-Cell, Diffuse/genetics/pathology [MESH]
  • |Lymphoma/*genetics/pathology [MESH]
  • |Male [MESH]
  • |Microarray Analysis [MESH]


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