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10.2174/1381612824666180110101052 http://scihub22266oqcxt.onion/10.2174/1381612824666180110101052 C6052765!6052765!29318961     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Pharm+Des 2018 ; 24 (3): 359-64 Nephropedia Template TP {{tp|p=29318961|t=2018. Targeting Na/K-ATPase Signaling: A New Approach to Control Oxidative Stress |pdf=|usr=}}{{29318961}} gab.com Text Targeting Na/K-ATPase Signaling: A New Approach to Control Oxidative Stress JO: Curr Pharm Des http://www.kidney.de/pget.php?&tw=1&pmid=29318961 #FOAvip Renal and cardiac function are greatly affected by chronic oxidative stress which can cause many pathophysiological states. The Na/K-ATPase is well-described as an ion pumping enzyme involved in maintaining cellular ion homeostasis; however, in the past two decades, extensive research has been done to understand the signaling function of the Na/K-ATPase and determine its role in physiological and pathophysiological states. Our lab has shown that the Na/K-ATPase signaling cascade can function as an amplifier of reactive oxygen species (ROS) which can be initiated by cardiotonic steroids or increases in ROS. Regulation of systemic oxidative stress by targeting Na/K-ATPase signaling mediated oxidant amplification improves 5/6th partial nephrectomy (PNx) mediated uremic cardiomyopathy, renal sodium handling, as well as ameliorates adipogenesis. This review will present this new concept of Na/K-ATPase signaling mediated oxidant amplification loop and its clinic implication. Twit Text FOAVip Targeting Na/K-ATPase Signaling: A New Approach to Control Oxidative Stress ????Curr Pharm Des http://www.kidney.de/pget.php?&tw=1&pmid=29318961 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29318961 #FOAvip English Wikipedia <ref>{{Cite pmid|29318961}}</ref> Targeting Na/K-ATPase Signaling: A New Approach to Control Oxidative Stress #MMPMID29318961 Liu J; Lilly MN; Shapiro JI Curr Pharm Des 2018[]; 24 (3): 359-64 PMID29318961show ga Renal and cardiac function are greatly affected by chronic oxidative stress which can cause many pathophysiological states. The Na/K-ATPase is well-described as an ion pumping enzyme involved in maintaining cellular ion homeostasis; however, in the past two decades, extensive research has been done to understand the signaling function of the Na/K-ATPase and determine its role in physiological and pathophysiological states. Our lab has shown that the Na/K-ATPase signaling cascade can function as an amplifier of reactive oxygen species (ROS) which can be initiated by cardiotonic steroids or increases in ROS. Regulation of systemic oxidative stress by targeting Na/K-ATPase signaling mediated oxidant amplification improves 5/6th partial nephrectomy (PNx) mediated uremic cardiomyopathy, renal sodium handling, as well as ameliorates adipogenesis. This review will present this new concept of Na/K-ATPase signaling mediated oxidant amplification loop and its clinic implication. äTargeting Na/K-ATPase Signaling: A New Approach to Control Oxidative S(epmc).pdf DeepDyve Pubget Overpricing