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The Tick Cell Biobank: A global resource for in vitro research on ticks, other
arthropods and the pathogens they transmit
#MMPMID29886187
Bell-Sakyi L
; Darby A
; Baylis M
; Makepeace BL
Ticks Tick Borne Dis
2018[Jul]; 9
(5
): 1364-1371
PMID29886187
show ga
Tick cell lines are increasingly used in many fields of tick and tick-borne
disease research. The Tick Cell Biobank was established in 2009 to facilitate the
development and uptake of these unique and valuable resources. As well as serving
as a repository for existing and new ixodid and argasid tick cell lines, the Tick
Cell Biobank supplies cell lines and training in their maintenance to scientists
worldwide and generates novel cultures from tick species not already represented
in the collection. Now part of the Institute of Infection and Global Health at
the University of Liverpool, the Tick Cell Biobank has embarked on a new phase of
activity particularly targeted at research on problems caused by ticks, other
arthropods and the diseases they transmit in less-developed, lower- and
middle-income countries. We are carrying out genotypic and phenotypic
characterisation of selected cell lines derived from tropical tick species. We
continue to expand the culture collection, currently comprising 63 cell lines
derived from 18 ixodid and argasid tick species and one each from the sand fly
Lutzomyia longipalpis and the biting midge Culicoides sonorensis, and are
actively engaging with collaborators to obtain starting material for primary cell
cultures from other midge species, mites, tsetse flies and bees. Outposts of the
Tick Cell Biobank will be set up in Malaysia, Kenya and Brazil to facilitate
uptake and exploitation of cell lines and associated training by scientists in
these and neighbouring countries. Thus the Tick Cell Biobank will continue to
underpin many areas of global research into biology and control of ticks, other
arthropods and vector-borne viral, bacterial and protozoan pathogens.
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