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10.1186/s12882-018-0967-5 http://scihub22266oqcxt.onion/10.1186/s12882-018-0967-5 C6052665!6052665 !30021637     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30021637 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMC+Nephrol 2018 ; 19 (1 ): 182 Nephropedia Template TP {{tp|p=30021637 |t=2018. Retrospective analysis of tacrolimus combined with Tripterygium wilfordii polyglycoside for treating idiopathic membranous nephropathy |pdf=|usr=}}{{30021637 }} gab.com Text Retrospective analysis of tacrolimus combined with Tripterygium wilfordii polyglycoside for treating idiopathic membranous nephropathy JO: BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=30021637 #FOAvip BACKGROUND: Idiopathic membranous nephropathy (IMN) is one of the most common adult nephrotic syndromes. Some patients with this disorder require immunosuppressive therapy. This retrospective case series was performed to assess the effects of tacrolimus (TAC) combined with Tripterygium wilfordii polyglycoside (TWG) in treating IMN. METHODS: From January 2015 to August 2016, kidney-biopsy-proven IMN patients treated with TAC in the Chinese PLA General Hospital were screened. Data were retrieved from the patients' medical records. The first efficacy evaluation index was remission rate (complete remission and partial remission), and the secondary efficacy evaluation indices included relapse rate, proteinuria, serum albumin and estimated glomerular filtration rate (eGFR). Adverse events were also assessed. RESULTS: The included patients' treatments were tacrolimus monotherapy (TAC group, n?=?33), tacrolimus combined with methylprednisolone (MP) (TAC?+?MP group, n?=?24) and tacrolimus combined with Tripterygium wilfordii polyglycoside (TAC?+?TWG group, n?=?21). The remission rates of the TAC, TAC?+?MP, and TAC?+?TWG groups in the 10th month were 54.5, 62.5, and 85.7%, respectively (TAC?+?TWG group vs TAC group, P?=?0.037, TAC?+?TWG group vs TAC?+?MP group, P?=?0.125). Moreover, the complete remission rates of the TAC, TAC?+?MP, and TAC?+?TWG groups in the 10th month were 21.2, 20.8, and 57.1%, respectively (TAC?+?TWG group vs TAC group, P?=?0.007, TAC?+?TWG group vs TAC?+?MP group, P?=?0.012). Compared with the TAC group, the TAC?+?TWG group had a higher remission rate during these ten months (log-rank, P?=?0.005). Compared with the TAC and TAC?+?MP groups, the TAC?+?TWG group had a higher complete remission rate (log-rank, P?=?0.019 and log-rank, P?=?0.005, respectively). CONCLUSION: This retrospective study showed that TAC combined with TWG may be effective for treating IMN. Further randomized controlled trials (RCTs) are needed to assess the efficacy and safety of TAC combined with TWG. Twit Text FOAVip Retrospective analysis of tacrolimus combined with Tripterygium wilfordii polyglycoside for treating idiopathic membranous nephropathy ????BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=30021637 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30021637 #FOAvip English Wikipedia <ref>{{Cite pmid|30021637 }}</ref> Retrospective analysis of tacrolimus combined with Tripterygium wilfordii polyglycoside for treating idiopathic membranous nephropathy #MMPMID30021637 Shang SL ; Cai GY ; Duan SW ; Li P ; Li QG ; Chen XM BMC Nephrol 2018[Jul]; 19 (1 ): 182 PMID30021637 show ga BACKGROUND: Idiopathic membranous nephropathy (IMN) is one of the most common adult nephrotic syndromes. Some patients with this disorder require immunosuppressive therapy. This retrospective case series was performed to assess the effects of tacrolimus (TAC) combined with Tripterygium wilfordii polyglycoside (TWG) in treating IMN. METHODS: From January 2015 to August 2016, kidney-biopsy-proven IMN patients treated with TAC in the Chinese PLA General Hospital were screened. Data were retrieved from the patients' medical records. The first efficacy evaluation index was remission rate (complete remission and partial remission), and the secondary efficacy evaluation indices included relapse rate, proteinuria, serum albumin and estimated glomerular filtration rate (eGFR). Adverse events were also assessed. RESULTS: The included patients' treatments were tacrolimus monotherapy (TAC group, n?=?33), tacrolimus combined with methylprednisolone (MP) (TAC?+?MP group, n?=?24) and tacrolimus combined with Tripterygium wilfordii polyglycoside (TAC?+?TWG group, n?=?21). The remission rates of the TAC, TAC?+?MP, and TAC?+?TWG groups in the 10th month were 54.5, 62.5, and 85.7%, respectively (TAC?+?TWG group vs TAC group, P?=?0.037, TAC?+?TWG group vs TAC?+?MP group, P?=?0.125). Moreover, the complete remission rates of the TAC, TAC?+?MP, and TAC?+?TWG groups in the 10th month were 21.2, 20.8, and 57.1%, respectively (TAC?+?TWG group vs TAC group, P?=?0.007, TAC?+?TWG group vs TAC?+?MP group, P?=?0.012). Compared with the TAC group, the TAC?+?TWG group had a higher remission rate during these ten months (log-rank, P?=?0.005). Compared with the TAC and TAC?+?MP groups, the TAC?+?TWG group had a higher complete remission rate (log-rank, P?=?0.019 and log-rank, P?=?0.005, respectively). CONCLUSION: This retrospective study showed that TAC combined with TWG may be effective for treating IMN. Further randomized controlled trials (RCTs) are needed to assess the efficacy and safety of TAC combined with TWG. |*Tripterygium [MESH] |Adult [MESH] |Drug Therapy, Combination [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Glomerulonephritis, Membranous/blood/*drug therapy/physiopathology [MESH] |Glycosides/*administration & dosage/isolation & purification [MESH] |Humans [MESH] |Immunosuppressive Agents [MESH] |Male [MESH] |Middle Aged [MESH] |Plant Extracts/*administration & dosage/isolation & purification [MESH] |Retrospective Studies [MESH] |Tacrolimus/*administration & dosage [MESH]Retrospective analysis of tacrolimus combined with Tripterygium wilfor(epmc).pdf DeepDyve Pubget Overpricing